YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis and Antiinflammatory-analgesic Activity of Cinmetacin Amides

Cinmetacin의 amide 유도체 합성과 항염진통활성

  • Published : 2001.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

Five novel cinmetacin amide derivatives as potential nonsteroidal antiinflammatory and analgesic compounds were prepared and their antiinflammatory-analgesic activity was compared with cinmetacin. Cinmetacin and hydroxysuccinimide were reacted with dicyclohexyl carbodiimide to give cinmetacin active ester (4), which was treated with amines to yield cinmetacin amides (5-9). Compounds (5) and (9) gave stronger analgesic activity than cinmetacin and compounds (5), (6), (9) showed comparable antiinflammatory activity to cinmetacin.

Keywords

References

  1. Nonsteroidal Antiinflammatory Drugs v.9 Current Nonsteroidal Antiinflammatory Drug Therapy in Rheumatoid Arthritis, with Emphasis on Use in the Elderly Buchanan W. W.;Kean W. F.
  2. Pharmacology(Third edition) v.251 Rang H. P.;Dale M. M.;Ritter J. M.
  3. Nonsteroidal Antiinflammatory Drugs(1st. ed.) Lombardino, J. G.
  4. Am. J. Med. v.77 no.57 Mechanism of action of nonsteroidal anti-inflammatory agents Goodwin, J. S.
  5. J. Med. Chem. v.12 no.176 1-Acylindoles. IX. Syntheses of 1-cinnamoyl-5methoxy-2-methyl-3-indolylaliphatic acids as potential antiinflammatory agents Yamamoto, H.;Nakao, M.
  6. Am. J. Med. v.81 no.58 Effects of nonsteroidal anti-inflammatory drugs in healthy subjects Sedor, J. R.;Davidson, E. W.;Dunn, M. J.
  7. Curr. Med. Res. Opin. v.5 no.648 Endoscopic study of the gastro-intestinal tolerance of glucamethacin Mirelli, E.;Fichera, G.;Volpe, A. D.;Lasala, M.
  8. Curr. Med. Res. Opin. v.12 no.332 Acemetacin and indomethacin in the treatment of rheumatoid arthritis: a double-blind comparative study in general practice Saul, P. A.;Korlipara, K.
  9. Proc. Soc. Exp. Med. v.111 no.544 Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs Winter, C. A.;Riskey, E. A.;Nuss, G. W.
  10. Fed. Proc. v.18 no.412 Acetic acid for analgesic screening Koster, R.;Anderson, M.;De Beer, E. J.