Biomolecules & Therapeutics
- Volume 9 Issue 3
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- Pages.167-175
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- 2001
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- 1976-9148(pISSN)
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- 2005-4483(eISSN)
Down-regulation of TNF-$\alpha$ and IL-6 by Higenamine is Responsible for Reduction of Infarct Size and Myocardial Ischemic Injury in the Rat
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Lee, Young-Soo
(Department of Pharmacology, Istitute of Hearth Science, College of Medicine, Gyeongsang National University) ;
- Kang, Young-Jin (Department of Pharmacology, Istitute of Hearth Science, College of Medicine, Gyeongsang National University) ;
- Lee, Bog-Kyu (Department of Pharmacology, Istitute of Hearth Science, College of Medicine, Gyeongsang National University) ;
- Ko, Young-Shim (Department of Pharmacology, Istitute of Hearth Science, College of Medicine, Gyeongsang National University) ;
- Park, Min-Kyu (Department of Pharmacology, Istitute of Hearth Science, College of Medicine, Gyeongsang National University) ;
- Seo, Han-Geuk (Department of Pharmacology, Istitute of Hearth Science, College of Medicine, Gyeongsang National University) ;
- Yun-Choi, Hye-Sook (Department of Pharmacology, Istitute of Hearth Science, College of Medicine, Gyeongsang National University) ;
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Chang, Ki-Churl
(Department of Pharmacology, Istitute of Hearth Science, College of Medicine, Gyeongsang National University)
- Published : 2001.09.01
Abstract
Recent studies have shown that cytokines are capable of modulating cardiovascular function and that some drugs used in the treatment of heart failure variably modulate the production of cytokines. Hige- namine, a positive inotropic isoquinoline alkaloid, has been used traditionally as cardiac stimulant, and reported to reduce nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression in LPS- and/or cytokine-activated cells in vitro and in vivo. Therefore, we investigated whether higenamine modulates the production of proinflammatory cytokines in myocardial infarction. In addition, effects of higenamine on antioxidant action and antioxidant enzyme expression (MnSOD) were studied. Myocardial infarction (MI) was confirmed by measuring left ventricular (LV) pressure after occlusion of the left anterior descending coronary artery (LAD) for 5 weeks in rats. Treatment of higenamine (10 mg/kg/day) reduced infarct size about 35 %, which accompanied by reduction of production TNF-