The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Effect of Jiaweizhengqi-tang on Motor Activity, Glucose Transport and Metabolism in Rat Small Intestine

가미정기탕(加味正氣湯)이 흰쥐 소장의 수송능과 글루코스 이동 및 대사에 미치는 영향

  • Park, Gyu-Taek (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Kim, Woo-Hwan (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Moon, Sun-Young (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Cho, Su-In (Dept. of Herbology, College of Oriental Medicine, Dong-Shin University)
  • 박규택 (동의대학교 한의과대학 소화기내과학교실) ;
  • 김우환 (동의대학교 한의과대학 소화기내과학교실) ;
  • 문선영 (동의대학교 한의과대학 소화기내과학교실) ;
  • 조수인 (동신대학교 한의과대학 본초학교실)
  • Published : 2001.09.30
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Abstract

Objectives; This study was carried out to investigate the motor activity, glucose transport and metabolism of Jiaweizhengqi-tang(JKT) in rat small intestine. Methods ; The motor activity of the rat small intestine has been investigated by means of measuring barium sulfate passage degrees. Transport and metabolism of glucose were studied in everted sac of rat small intestine with incubation under several conditions. Results; Atropine treatment significantly delayed barium sulfate transit, and JKT pretreatment increased intestinal motor activity, but not significant. JKT administration showed renal toxicity in animal experiment, so clinical safety should settled to use commonly. The transport and metabolism of glucose were greater at jejunum than ileum. So, everted jejunum of rat were used to study the effect of JKT. When JKT were treated, the concentration of glucose were higher than untreated group. This result was thought to be influenced by the glucose in JKT. When 2, 4 dinitrophenol was treated, the transport and metabolism of glucose were decreased, but JKT treated together, the concentration of glucose in serosal solution increased. Conclusions; The transport and metabolism of glucose were influenced by the glucose in JKT. And the effects of JKT were still unidentified, but through continuous investigation, these effects of JKT should be identified.

Keywords

References

  1. 症狀別 臨床檢査 醫學敎育硏修院(編著)
  2. 家庭醫學 醫學敎育硏修院(編著)
  3. 萬病回春 공廷賢(撰)
  4. 中華名醫方劑大全 彭懷仁
  5. 標準臨床方劑學 裵秉哲
  6. 생리학 v.11장 강두희
  7. Life Sci v.31 no.20;21 Morphine inhibits gastrointestinal transit in the rat primarily by imparing propulsive activity of the small intestine Fiocchi, R.;Bianchi, G.;Petrillo, P.;Tavani, A.;Manara, L.
  8. J Pharmacol Exp Ther v.238 no.2 Cholinergic neurons mediate intestinal propulsion in the rat Galligan, J.J.;Burks, T.F.
  9. Gen Pharmacol v.18 no.3 Motor activity of the rat duodenum in vivo : evidence for the existence of an atropin-resistant peristalsis Maggi, C.A.;Santicioli, P.;Giuliani, S.;Meli, A.
  10. Neurogatroenterol Motil v.11 no.3 Motor activity of vas-cularly perfused rat duodeum. 1. Characteristics of spontaneous move-ment Yamamoto, H.;Kuwahara, A.;Yamamoto, I.;Fujimora, M.;Maeda, T.;Fujimiya, M.
  11. Eur J Pharmacol v.303 no.1;2 Influence of age on cholinergic and inhibitory nonadrenergic noncholinergic responses in the rat ileum Smits, G.J.;Lefebvre, R.A.
  12. Am J Hosp Pharm v.43 no.1 Barium sulfate products for roentgenographic examination of the gastrointestinal tract McKee, M.W.;Jurgens, R.W. Jr.
  13. Am J Vet Res v.43 no.1 Radiologic observations of gastric and small intestinal motility in suckling pigs Wood, A.K.
  14. Lab Anim Sci v.43 no.6 Anatomic features and radiographic observations of gastric emptying and small intestinal motility in the rat Perry, R.L.;Carrig, C.B.;Williams, J.F.;Johnson, C.A.;Kaneene, J.B.
  15. Am J Physiol v.249 no.6 Effect of atropine on digested food-induced intestinal hyperemia Nyhof, R.A.;Ingold-Wilcox, D.;Chou, C.C.
  16. J Physiol(Lond) v.365 no.1 Metabolic energy dependence of glucose, water and sodium absorption in the presence and absence of downhill sodium gra-dients across isolated rat small intestine Gardner, M.L.
  17. Proc Soc Exp Biol Med v.188 no.2 Ouabain-insensitive transport in the rat jejunum incubated in vitro Tosco. M.;Orsenigo, M.N.;Esposito, G.;Faelli, A.
  18. Surgery v.94 no.2 Ethanol inhibition of glucose absorption in isolated, pefused small bowel of rats Cobb, C.F.;Van Thiel, D.H.;Wargo, J.
  19. Am J Physiol v.258 no.1 Effects of phlorizin and sodium on glucose-elicited alterations of cell junctions in intestinal epithelia Atisook, K.;Carlson, S.;Madara, J.L.
  20. Biological & Pharmaceutical Bulletin v.19 no.7 Absorption of Methochlorpromazine in Rat Small Intestinal Everted Sac Shuji Kitagawa;Katsuya Sato;Shinji Sato;Masanori Sasaki
  21. Biological & Pharmaceutical Bulletin v.20 no.4 Basic Studies On 5-(7-Hydroxy-3-Phosphonocholyl) Aminosalicylic Acid For The Evaluation Of Microbial Overgrowth Konishi, T.;Takahashi, M.;Ohta, S.
  22. Human Gene Therapy v.9 no.8 Toxin Gene-Mediated Growth Inhibition of Lung Adenocarcinoma In An Animal Model Of Pleural Malignancy Hoganson, D.K.;Matsui, H.;Batra, R.K.;Boucher, R.C.
  23. Pharmaceutical Research v.15 no.6 Interaction Of A Self-Emulsifying Lipid Drug Delivery System With The Everted Rat Intestinal Mucosa As A Function Of Drople Size And Surface Charge Gershanik, T.;Benzeno, S.;Benita, S.
  24. International Journal of Pharmaceutics v.183 no.1 Studies on the uptake of tomato lectin nanoparticles in everted gut sacs Carreno-Gomez, B.;Woodley, J.F.;Florence, A.T.
  25. Biological & Pharmaceutical Bulletin v.22 no.10 Release characteristics of endogenous constituents by exposure of small intestine to modified beta-cyclodextrins Tanino, T.;Ogiso, T.;Iwaki, M.;Yamaguchi, T.;Kakehi, K.
  26. Journal of Phar-macology & Experimental Thera-peutics v.292 no.1 Involvement of an organic anion transporter (canalicular multispecific organic anion transporter/multidrug resistance - associated protein 2) in gastro-intestinal secretion of glutathione conjugates in rats Gotoh, Y.;Suzuki, H.;Kinoshita, S.;Hirohashi, T.;Kato, Y.;Sugiyama, Y.
  27. Arzneimittel - Forschung v.50 no.6 Effect of polyoxyl 35 castor oil and polysorbate 80 on the intestinal absorption of digoxin in vitro Cornaire, G.;Woodley, J.F.;Saivin, S.;Legendre, J.Y.;Decourt, S.;Cloarec, A.;Houin, G.
  28. 醫學輯要 宋店植
  29. 精校黃帝內經素問 洪元植(交合編纂)
  30. 精校黃帝內經靈樞 洪元植(交合編纂)
  31. 수의생리학실험 양일석