Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effects of the Water Extract from the Stem Bark of Acanthopanax senticosus on Hyperlipidemia in Rats

가시오갈피 줄기의 물 추출물이 지질대사에 미치는 영향

  • Lee, Yeon-Sil (Natural Products Research Institute, Seoul National University) ;
  • Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University) ;
  • Lim, Soon-Sung (Natural Products Research Institute, Seoul National University) ;
  • Ji, Jun (Natural Products Research Institute, Seoul National University) ;
  • Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University)
  • 이연실 (서울대학교 천연물과학연구소) ;
  • 정상훈 (서울대학교 천연물과학연구소) ;
  • 임순성 (서울대학교 천연물과학연구소) ;
  • 지준 (서울대학교 천연물과학연구소) ;
  • 이상현 (서울대학교 천연물과학연구소) ;
  • 신국현 (서울대학교 천연물과학연구소)
  • Published : 2001.06.30
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Abstract

The effects of the water extract from the stem bark of Acanthopanax senticosus were evaluated on hyperlipidemic rats induced by lipid rich diet or poloxamer-407. The water extracts, when administered orally for 3 consecutive days in hyperlipidemic rats induced by poloxamer-407 (1 ml of 30%), was found to cause a significant decrease in plasma cholesterol and triglyceride concentrations. The water extracts, when treated orally for 5 consecutive days also showed a significant inhibition of serum total cholesterol and triglyceride level in rats treated with lipid rich diet (15% cholesterol, 1% sodium cholate and 84% com oil). HDL-cholesterol, however, was increased significantly.

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