Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Induction of Quinone Reductase by Extracts of Traditional Medicinal Plants

Quinone reductase 유도활성 측정에 의한 약용식물의 항암활성 검색

  • Jin, Hai-Hong (Department of Biotechnology, Graduate School, Handong University) ;
  • Kim, Dong-Man (Yanbian University of Science and Technology, Department of Biochemical Engineering) ;
  • Hyun, Chang-Kee (School of Bioscience and Food Technology, Handong University)
  • 김해홍 (한동대학교 대학원 생명공학과) ;
  • 김동만 (연변과학기술대학 생물화공과) ;
  • 현창기 (한동대학교 생물식품공학부)
  • Published : 2001.06.30
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Abstract

Induction of phase II enzymes is a major mechanism of chemoprevention. The induction levels of quinone reductase (QR) activity in cultured murine hepatoma (Hepa 1c1c7) cells by 80%-methanol extracts of traditional medicinal plants were measured. Among the tested 81 plants, the extracts of Aralia continentalis, Magnolia obovata, and Viscum album were found to induce QR activities over 250%. The maximum induction levels obtained were 401.9%, 270.5%, and 301.8% by treatments of the extracts of A. continentalis $(318\;{\mu}g/ml)$, M. obovata $(53.8\;{\mu}g/ml)$ and V. album $(80.6\;{\mu}g/ml)$, respectively. These QR induction activities were more potent than those of the known QR inducers, t-butylhydroquinone (170.1%) and ${\beta}-naphthoflavone$ (320.0%).

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