혜화의학회지 (Journal of Haehwa Medicine)

  • 제9권1호
  • /
  • Pages.169-182
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  • 2000
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  • 2586-3002(pISSN)
  • /
  • 2586-3347(eISSN)
대전대학교 한의학연구소 (Research Institute of Korean Medicine)
권호 표지

부정양음양(扶正養陰陽)의 항암활성(抗癌活性)에 관(關)한 연구(硏究)(I)

Study on Antitumor Activity of Bujeongyangeumtang(BJYET)

  • 송민호 (대전대학교 한의과대학 병리학교실) ;
  • 최봉균 (푸른한의원) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Song, Min-Ho (Dept. of Oriental Medicine Pathology, College of Oriental Medicine, Taejon University) ;
  • Choe, Bong-Gyun ;
  • Kim, Dong-Hee (Dept. of Oriental Medicine Pathology, College of Oriental Medicine, Taejon University)
  • 발행 : 2000.08.25
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초록

To evaluate the antitumor activity and antimetastatic effects of Bujeongyangeumtang(BJYET), studies were done experimentally. The results were obtained as follows: 1. BJYET extracts exhibited a significant cytotoxicity against A549, SK-MEL-2, SK-OV-3 and B16-BL6 cell lines. 2. The T/C% was 118.2% in BJYET treated group in S-180 bearing ICR mice. 3. BJYET extracts exhibited inefficient adhesive effect of A549, B16-BL6 cell to complex extracellular matrix. 4. BJYET extracts showed a significant inhibition of lung metastasis of B16-BL6 cells in C57BL/6. 5. In vitro neovascularization assays, angiogenesis was significantly inhibited in BJYET treated group than control group. These results suggested that BJYET extracts might be usefully applied for prevention and treatment of cancer.

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