혜화의학회지 (Journal of Haehwa Medicine)

  • 제9권1호
  • /
  • Pages.155-167
  • /
  • 2000
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  • 2586-3002(pISSN)
  • /
  • 2586-3347(eISSN)
대전대학교 한의학연구소 (Research Institute of Korean Medicine)
권호 표지

고본거어1호방(固本祛瘀1號方)의 항암활성(抗癌活性)에 관(關)한 연구(硏究)(I)

Study on Antitumor Activity of Gobongeer1hobang(GG1B)

  • 서인원 (대전대학교 한의과대학 병리학교실) ;
  • 김성훈 (경희대학교 동서의학대학원 한방종양학교실) ;
  • 최봉균 (푸른한의원) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • 발행 : 2000.08.25
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초록

To evaluate the antitumor activity and antimetastatic effects of Gobongeerlhobang(GG1B), studies were done experimentally. The results were obtained as follows: 1. GG1B extracts exhibited a significant cytotoxicity against HT1080, A549, SK-MEL-2 and SK-OV-3 cell lines. 2. The T/C% was 120.7% in GG1B treated group in S-180 bearing ICR mice. 3. GG1B extracts exhibited inefficient adhesive effect of A549, B16-BL6 cell to complex extracellular matrix. 4. GG1B extracts showed a significant inhibition of lung metastasis of B16-BL6 cells in C57BL/6. 5. In CAM assays, angiogenesis was insignificantly inhibited in GG1B treated group than control group. These results suggested that GG1B extracts might be usefully applied for prevention and treatment of cancer.

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