Cited by
- 두발용 퍼머 약제인 Thioglycolic Acid의 투과 영향 vol.19, pp.1, 2000, https://doi.org/10.12925/jkocs.2002.19.1.3
Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)
- Volume 17 Issue 2
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- Pages.126-131
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- 2000
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- 1225-9098(pISSN)
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- 2288-1069(eISSN)
DOI QR Code
Skin Permeation Characteristics of Antihyperlipoproteinemic Agent using Natural Polymer Bases in Rats
천연고분자 기재에 의한 수용성 항고지단백혈증제의 흰쥐 피부투과 특성
- Kong, Seung-Dae (Dept. of Chemical engineering, Myong Ji University) ;
- Hwang, Sung-Kwy (Dept. of Chemical engineering, Myong Ji University) ;
- Jung, Duck-Chae (Dept. of chemistry, University of Inchon)
- Published : 2000.06.30
Abstract
Transdermal therapeutic system(TTS) is often used as the method of drug dosage into the epidermic skin. Natural polymer were selected as ointment material of TTS. We investigated the permeation of natural polymer ointment containing drug in rat skin using horizontal membrane cell model. Permeation properties of materials were investigated for water-soluble drug such as oxiniacic acid in vitro. These results showed that skin permeation rate of drug across the composite was mainly dependent on the property of ointment base and drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. This result suggests a possible use of natural polymer ointment base as TTS of antihyperlipoproteinemic agent.
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