The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Role of $17{\beta}$- Estradiol on Brain Atrophy Following Cerebral Infarction

뇌졸중후 뇌위축에 대한 조경론적 접근

  • 윤상협 (경희대학교 동서의학연구소) ;
  • 이종수 (경희대학교 한의과대학 재활의학과)
  • Published : 2000.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : The aim of this study was to investigate the neuroprotection effect of estrogen on brain atrophy following cerebral infarction. Method : All animals in this study were classified into 4 groups; ovariectomy group (OVXgroup), cerebral infarction group (INF group), combination ovariectomy and cerebral infarction group (OVX + INF group), and naturally intact group for control data (NOR group). Cerebral infarction was made by Chen's method with some modification. Ovariectomy was performed by Wayforth's method. Experimental data for each group was collected at 15 days, month, 3 months, and 6 months after starting observation. Serum $17{\beta}-estradiol(E2)$ was determined by radioimmunoassay. Brain volume was measured and calculated with image analysis. Each brain was sliced at intervals of 2mm in chamber after 30 min of freezing in refregerater. Cerebral volume was obtained by sum of volume of each slice level, which was mean $area{\;}{\times}{\;}2mm$. Results : Cerebral ischemia was found to decrease the serum concentration of $17{\beta}-{\;}estradiol(E2)$ and to inhibit the physiologically conpensatary function of the ovariectomized rats. Also we found that deprivation of estrogen have resulted in more severe cerebral atrophy followed by cerebral infarction. Conclusion : It is suggested that estrogen has a neuroprotection effect on cerebral atrophy following cerebral infarction.

Keywords

References

  1. 胎産心法 閻純彌
  2. 中醫婦科學 羅元愷
  3. 한방부인과학 宋炳基
  4. 대한한의학회지 v.8 no.2 閉鎖性腦卒中에 대한 임상적 연구 배철환;이경섭
  5. 대한한의학회지 v.7 뇌졸중에 대한 동서의학적 고찰 오세붕
  6. 대한한의학회지 v.7 원발성 뇌실질내출혈에 관한 임상적 고찰 조기호;이경섭
  7. 부인과학 대한산부인과학회
  8. Obstet Gynecol. v.75 no.supple4 Cardiovascular implications of estrogen replacement therapy Loho RA.
  9. Osteoporosis Cecil textbook of medicine Riggs BL.;Wyngarrdin JB;Smith LH(eds)
  10. Neuro-psychiatry Clin. Neurosci. v.7 Lack of postmenopusal estrogen replacement therapy and risk of dementia Motel KF;Meyer JS.
  11. the Spine Rothmann RH;Simeone FA.
  12. Lancet v.352 no.9145 Cardiovascular and cancer morbidity and mortality and sudden cardiac death in postmenopausal women on oestrogen replcement therapy(ERT) Sourander L;Rajala T;Erkkola R;Helenius H.
  13. Arch Intern Med. v.153 Hormone replacement therapy and the risk of stroke. Follow-up of a population-based cohort in Sweden Falkeborn M;Persson I.
  14. Engl J Med. v.329 Cardiovascular health and diseases in women Wenger NK;Speroff L.;Packard B.
  15. Stroke v.29 Gender-linked brain injury in experimental stroke Alkayed NJ;Harukuni I;Kimes AS;London ED;Traystman RJ;Hurn PD.
  16. J of Cerebral Blood Flow and Metabolism v.11 Sex difference in postischemic neuronal necrosis in gerbils Hall ED;Pazara KE;Linseman KL.
  17. Stroke v.17 A model of focal ischemic stroke in the rat : reproducible extensive cortical infarction Chen ST;Hsu CY;Hogan EL;Maricq H;Balentine JD.
  18. Experimental and surgical technique in the rat Waynforth HB.
  19. J. Neurochem. v.66 Estrogen attenuate and corticosterone exacerbates exicitotoxicity, oxidative injury and amyloid peptide toxicity in hippocampal neurons Goodman Y;Bruce AJ;Cheng B;Mattson MP.
  20. Osteoporosis Cecil textbook of medicine Riggs BL;Wyngarrden JB;Smith LH(eds)
  21. Brain Research v.761 17${\beta}$-estradiol protects against NMDA-induced exitotoxicity by direct inhibition of NMDA receptors Weaer CE;Chung MP;Gibbs TT;Farb DH.
  22. Exp Neurol. v.129 Effect of estrogen replacement of the relative levels of choline acetyltransferase,trka,and nerve growth factor messenger rnas in the basal forebrain and hippocampal formation of adults rats Gibbs RB;Wu D;Hersh LB;Pfaff DW
  23. J Neurosci. v.16 The effects of ovariectomy and estrogen replacement mrna expression in the basal forebrain on the adult female Sprague-Dawly rat McMillan PJ;Singer CA;Dorse DM.
  24. Neurology v.38 Thalamic infarcts: clinical cyndromes, etiology, and prognosis Bogousslavsky J;Regli F;Uske A.
  25. Neurology v.34 Nonhemoohagic infarction of the thalamus:Behavioral, anatomic, and physiologic correlates Graff-Radford NR;Eslinger PJ;Damasio AR;Yamada T.
  26. Stroke v.22 Thalamic atrophy following cerebral infarction in the territory of the middle cerebral artery Tamura A;Tahira Y;Nagashima H;Kirino K;Gotoh K;Hojo;Sano K.
  27. 경희대학교 논문집 v.14 승금단이 난소기능에 미치는 영향 강명자;송병기
  28. 경희한의대논문집 v.6 조경종옥탕이 난소기능에 미치는 영향 송병기;이경섭
  29. 경희한의대논문집 v.18 no.2 온포산이 난소기능에 미치는 영향 이명진;이경섭;송병기
  30. 경희한의대논문집 v.6 통경탕이 배란 및 임신유지에 미치는 영향 정봉천;구본홍
  31. Brain Research v.784 Effects of gender and estradiol treatment on focal brain ischemia Zhang YQ;Shi J;Rajakumar G;Day AL;Simpkins JW.
  32. Stroke v.21 Progressive shrinkage of the thalamus following middle cerebral artery occlusion in rats Fujie W;Kirino T;Tomukai N;Iwasawa T;Tamura A.
  33. Stroke v.21 Neuronal damage in rat thalamus after cortical infarcts Iizuka H;Sakatani K;Young W.
  34. 신경외과학 대한신경외과학회
  35. Brain Research v.618 Chronological atrophy after transient middle cerebral artery occlusion in rats Hara H;Harada K;Sukamoto T.
  36. Ann Intern Med. v.132 no.9 Postmenopausal hormone therapy increases risk for venous thromboembolic disease. The heart and estrogen/progestin replacement study Grady D;Wenger NK;Herrington D;Khan S;Rurberg C;Hunninghake D;Vittinghoff E;Hulley S.
  37. Arterioscler Throm Vasc Biol. v.20 no.5 Postmenopausal hormone replacement therapy increases coagulaton activity and fibrinolysis Teede HJ;Mcgrath BP;Smolich JJ;Malan E.;Kotsopoulos D.;Liang YL;Peverll RE.
  38. Journal of Traditional Medicine v.13 Kampo medicine and neuroendocrine from here to molecular biology Hagino N.