The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effects of Sophorae Radix Fractionations on Cardiovascular Anaphylaxis in Pithed Rats

고삼 전탕액 분획물이 순환기 Anaphylaxis에 미치는 영향

  • 권강범 (원광대학교 한의과대학 생리학교실) ;
  • 김구환 (원광대학교 한의과대학 생리학교실) ;
  • 전영석 (원광대학교 한의과대학 생리학교실) ;
  • 조현익 (원광대학교 한의과대학 생리학교실) ;
  • 김영석 (군산대학교 해양과학대학 해양생명의학교실) ;
  • 박관하 (군산대학교 해양과학대학 해양생명의학교실) ;
  • 백승화 (원광대학교 한의학 전문대학원) ;
  • 류도곤 (원광대학교 한의과대학 생리학교실)
  • Published : 2000.06.01
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Abstract

Objectives and Methods : Unlike respiratory anaphylaxis responses, mediators responsible for cardiovascular responses are not clearly elucidated. Main characteristics of cardiovascular anaphylaxis include hypotension and cardiac failure (anhythmia and cardiac contraction failure). In this experiment, the fractionations of Sophorae Radix (SR) were tested for its preventive effects against cardiovascular anaphylaxis in pithed rats. Results : Of the SR fractionations, water fractions, at the concentration of 20 and 60mg/kg, was significantly effective on all the cardiovascular changes in pithed rats. Also, of the cardiovascular changes, depressor response was significantly attenuated by the ethyl acetate (EA) fraction, at the concentration of 60mg/kg. Conclusions : These results suggest that water and EA fractions of the SR fractionations possess anti. anaphylactic effects in pithed rats. Additional research is needed to identify active principles for the observed pharmacological effects.

Keywords

References

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