The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

The Experimental Study on the Animal Stroke Model of Oriental Medicine

한의학적 중풍 동물 모델 설정을 위한 실험적 연구

  • 채한 (경희대학교 한의과대학 생리학교실) ;
  • 이현삼 (경희대학교 동서의학대학원 신경과학교실) ;
  • 홍무창 (경희대학교 한의과대학 생리학교실)
  • Published : 2000.01.01
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of the present study was to explore the proper method for animal stroke model of Oriental medicine To this end, brain ischemia was induced by distal middle cerebral artery occlusion(dMCAO) and proximal middle cerebral artery occlusion(pMCAO) and evaluated with the method of Triphenyl Tetrazolium Chloride (TTC) staining and Swimming Behavior Test. Results demonstrated that first, infarct size and volume of pMCAO group were significantly bigger that those of dMCAO group. Second, analysis of swimming behavior test revealed that the percentage of left turning angles of pMCAO was significantly bigger than that of dMCAO. Third, during swimming behavior test, there were peculiar traces of small successive circles that represent motor dysfunction and conscious disturbance among dMCAO group. The results of the study thus indicate that non-invasive intraluminal method of pMCAO was the appropriate animal stroke model for Oriental medicine in the light of brain ischemia as hemiplesia and conscious disturbance.

Keywords

References

  1. 임상중풍학 김영석
  2. 중풍 동물 모델의 운동기능실조에 대한 연구 우태율
  3. 東醫心系內科學(下) 全國韓醫科大學 心系內科學敎室
  4. 한국심리학회지 v.5 흰쥐의 내측중격핵 손상이 MORRIS수중미로과제의 학습에 미치는 효과 정봉교(외 2인)
  5. J Cereb Blood Flow Metab. v.15 Time-related neuronal changes following middle cerebral artery occlusion:Implications for therapeutic intervention and the role of calpain Bartus RT;Dean RL;Cavanaugh K;Eveleth D;Carriero D;Lynch G
  6. Stroke v.17 Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination Bederson JB;Pitts LH;Tsuji M;Nishimura MC;Davis RL;Bartkowski H.
  7. Stroke v.17 A model of focal ischemic stroke in the rat. Reproduciblc extensive cortical infarction Chen ST;Hsu CY;Hogan EL;Maricq H;Balentine lJD.
  8. Stroke v.13 Middle celebral artery occlusion in the young fat Coyle P.
  9. Stroke v.23 Neurological and Behavioral Outcomes of Focal Celebral Ischemia in Rats Florence Wahl;Monique Allix;Michel Plotkine;,Roger G.
  10. Stroke v.20 Rodent Model of Cerebral Ischemia Ginsberg MD;Busto R
  11. Stroke v.24 Paw-rearching, sensorimotor, and rotational behavior after brain infarction in rats Grabowski M;Brundin P;Johansson BB.
  12. Cerebrovascular Diseases-Sixteenth Research(Princeteon) Conference Protective effects of the NMDA antagonist, MK-801, on focal ischemic Graham Dl;Ozyurt E;Park CK;Nehls DG;Teasdale GM;McCulloch J;Ginsberg MD;Dietrich WD(eds)
  13. J. Neurol. Sci. v.77 Recovery of integrative central nervous function after one hour global celebro-circulatory arrest in normothermic cat Hossman, K. A.;Schmidt-Kastner, R.;GrosseOphoff, B.
  14. Handbook of Psychophannacology v.19 chemical pathways in the brain Iversen LL;Iversen SD;Snyder SH
  15. J Neuropathol Exp Neurol. v.17 Neuropathological aspects of brain dedma Klatzo I.
  16. Jpn J Stroke v.17 Experimental studies of ischemic brain edema, I . a new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area Koisumi J;Yoshida Y;Nakazawa T;Ooneda G.
  17. Stroke v.24 Middle cerebral artery occlusion without craniectomy in rats. Which method works best? Laing RJ;Jakubowshi J;Laing RW
  18. Stroke v.27 Ginsberg;Middle Cerebral Artery Occlusion in the Rat by lntraluminal Suture Neurological and Pathological Evaluation of an Improved Model Ludmila Belayev;Ofelia F. Alonso;Raul Busto;Weizhao Zhao;Myron D
  19. Brain Res. v.575 Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats Markgraf CG;Green EJ;Hurwitz BE;Morikawa E;Dietrich WD;McCabe PM;Ginsberg MD
  20. Stroke v.25 Recovery of sensorimotor function after distal middle cerebral artery photothrombotic occlusion in rats Markgraf CG;Green EJ;Watson B;McCabe PM;Schneiderman N;Dietrich WD;Ginsberg MD
  21. J Cell Biol. v.66 Adhesion of cells to surfaces coated with polylysine Mazia D;Schatten G;Sale W
  22. Cerebrovasc. Dis. v.4 Delayed treatment with a noncompetitive NMDA antagonist, CNS-1102, reduces infarct size in rats Meadows ME;Fisher M;Minematsu K
  23. Neurology v.43 Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitively assessed by diffusion-weighted MRI Minematsu K;Fisher M;Li L;Davis MA;Knapp AG;Cotter RE;McBurney RN;Sotak CH
  24. Ann Neurol. v.18 Effect of pretreatment with the calcium antagonist nimodipine on local cerebral blood flow and histopathology after middle cerebral artery occlusion Mohamed AA;Gotoh O;Graham DI;Osborne KA;McCulloch J;Mendelow AD;Teasdale GM;Harper AM
  25. Stroke v.7 A classification of experimental models of brain ischemia Molinari GF;Laurent JP
  26. Neurobiology of the hippocampus An attempt to dissociate spatial mapping and working-memory theories of hippocampal funtion Morris RGM;W Seifert(eds.)
  27. Cerebrovascular diseases, 11th Princeton conference Morphological validation of ischemic stroke models Mossy J;Price TR;Nelson E(eds.)
  28. Acta Neurol scand. v.77 Mechanism of brain damage in focal ischemia Nedergaard M
  29. Stroke v.4 Transorbital approach for occluding the middle cerebral artery without craniectomy O'brien MD;Waltz AG
  30. J. Neurosurg. v.69 Effect of opiate antagonists on middle cerebral artery occlusion infarct in the rat Obana, W.G.;Pitts, L.H.;Nishimura, M.C.
  31. Neuroscience v.79 no.4 Chronic cerebral hypoperfusion by permanent internal carotid ligation produces learning impairment without brain damage in rats Ohta H;Nishikawa H;Kimura H;Anayama H;Miyamoto M
  32. J. Neurosci. v.9 Differential effects of fornix and caudate nucleus lesions on two radial maze tasks:evidence for multiple memory systems Packard, M.G.;Hirsch, R.;White, N.M.
  33. Brain Res. v.188 The differential effect of right versus left hemispheric cerebral infarction on cathcholamines and behavior in the rat Robinson RG
  34. Nature v.255 Effect of experimental cerebral infarction in rat brain on catecholamines and behavior Robinson RG;Shoemaker WJ;Schlumpf M;Valk T;Bloom TE
  35. Science v.205 Differential behavior and biochemical effects of right and left hemispheric infarction in the rat Robinson RG
  36. Eur J Pharmacol v.305 no.1;3 Pharmacological studies of a novel prolyl endopeptidase inhibito, JTP-4819, in rats with middle cerebral artery occlusion Shinoda M;Matsuo A;Toide K
  37. J Cereb Blood Flow Metab v.1 Focal cerebral ischemia in the rat:1.Description of technique and early neuropathological consequences following middle cerebral artery occlusion Tamura A;Graham DI;McCulloch J;Teasdale GM
  38. Stroke v.20 Interrelationship of brain edema, motor deficits and memory impariment in rats exposed to focal ischemia Tominaga T;Ohnishi ST
  39. Ann Neurol. v.17 Introduction of reproducible brain infarction by photochemically initiated thrombosis Waston B;Dietrich W;Busto R;Wachtel M;Ginsberg M
  40. Stroke v.20 Reversible middle cerebral artery occlusion without craniectomy in rats Zea Longa EL;Weinstein PR;Carlson S;Cummins R