Archives of Pharmacal Research
- Volume 23 Issue 6
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- Pages.626-632
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Brazilin Augments Cellular Immunity in Multiple Low Dose Streptozotocin (MLD-STZ) Induced Type I Diabetic Mice
- Yang, Kyoung-Mee (College of Pharmacy, Seoul National University) ;
- Jeon, Sun-Duck (College of Pharmacy, Seoul National University) ;
- So, Dhong-Soo (College of Pharmacy, Seoul National University) ;
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Moon, Chang-Kiu
(College of Pharmacy, Seoul National University)
- Published : 2000.12.01
Abstract
Brazilin, an active principle of Caesalprenia sappan, was examined for its immunopotentiating effects in multiple low dose streptozotocin (MLD-STZ) induced type diabetic mice. Brazilin was intraperitoneally administered for 5 consecutive days to MLD-STZ induced type 1 diabetic mice. Delayed type hypersensitivity, Con A-induced proliferation of splenocytes and mixed lymphocyte reaction, which had been decreased in diabetic mice, were significantly recovered by the administration of brazilin. Brazilin increased IL-2 production without affecting suppressor cell activity. Con A-induced and IL-2-induced expression of high affinity IL-2 receptors were also enhanced by brazilin. These results indicate that brazilin augments cellular immune responses, which are suppressed in the MLD-STZ induced type I diabetic mice, by increasing IL-2 production and responsiveness of immune cells to IL-2.
Keywords
- Brazilin;
- Immunomodulating agents;
- Type I diabetes;
- Delayed type hypersensitivity;
- Mixed lymphocyte reaction;
- Proliferation;
- Splenocytes;
- IL-2