Archives of Pharmacal Research
- Volume 23 Issue 6
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- Pages.554-558
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Modulation of NAD(P)H:Quinone Oxidoreductase (NQO1) Activity Mediated by 5-Arylamino-2-methyl -4,7-dioxobenzothiazoles and their Cytotoxic Potential
- Ryu, Chung-Kyu (College of Pharmacy, Ewha Womans University) ;
- Jeong, Hyeh-Jean (College of Pharmacy, Ewha Womans University) ;
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Lee, Sang-Kook
(College of Pharmacy, Ewha Womans University)
;
- Kang, Hye-Young (College of Pharmacy, Ewha Womans University) ;
- Ko, Kyung-Min (College of Pharmacy, Ewha Womans University) ;
- Sun, Yang-Jung (College of Pharmacy, Ewha Womans University) ;
- Song, Eun-Ha (College of Pharmacy, Ewha Womans University) ;
- Hur, Yeon-Hoe (College of Pharmacy, Ewha Womans University) ;
-
Lee, Chong-Ock
(Korea Research Institute of Chemical Technology)
- Published : 2000.12.01
Abstract
Synthesized 5-arylamino-2-methyl-4,7-dioxobenzothiazoles 3a-3o were evaluated for modulation of NAD(P)H: quinone oxidoreductase (NQOl) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several human solid cancer cell lines. The 4,7-dioxobenzothiazoles affected the reduction potential by NQOl activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 3a, 3b, 3g, 3h, 3n and 3o were considered as more potent cytotoxic agents, and comparable modulators of NQOl activity.
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