Archives of Pharmacal Research
- Volume 23 Issue 6
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- Pages.559-563
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Antiviral Activity of Novel Methylene Cyclopropyl Nucleosides
- kwak, Eun-Yee (Department of Medicinal Chemistry, College of Pharmacy, Chonnam National University) ;
- Hong, Joon-Hee (Department of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
- Lee, Chong-Kyo (Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology) ;
- Choi, Bo-Gil (Department of Medicinal Chemistry, College of Pharmacy, Chonnam National University)
- Published : 2000.12.01
Abstract
Novel exomethylene cyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate 5 was synthesized in 4 steps, from Feists acid 1 and was condensed with purine derivatives by the