Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Stability in Effects of ${\gamma}$-Irradiated Chinese Medicinal Prescriptions on Protection of Mice from Radiation

감마선조사 한약의 방사선방호 효능 안정성

  • 양정아 (전남대학교 수의과대학) ;
  • 김성호 (전남대학교 수의과대학) ;
  • 김세라 (전남대학교 수의과대학) ;
  • 유영법 (한국원자력연구소 방사선식품·생명공학기술개발팀) ;
  • 조성기 (한국원자력연구소 방사선식품·생명공학기술개발팀)
  • Published : 2000.06.01
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Abstract

건조 농산물을 비롯한 식품에 대한 방사선 조사가 허가, 시행되고 있으며, 그 적용 범위도 확대되고 있다. 이에 따라 건조 생약재의 위생화의 대체방법으로 방사선 조사 기술의 적용이 산업계로부터 요구되고 있다. 본 연구는 감마선 조사 생약재의 효능 변화 유무를 확인하기 위한 일환으로 수행되었다. 저자 등은 사물탕, 보중익기탕 및 삼령백출산 등이 방사선 방호 효과를 보이는 것으로 이미 보고한 바 있다. 본 실험에서는 감마선 조사(10 kGy)한 이들 한약제 각각의 방사선 방호 효과를 비조사 시료와 비교 평가하였다. 효과평가를 위하여 방사선 조사 마우스에서 소장움 생존시험, 내재성 비장집락 형성시험 및 apoptosis 측정을 시행하였다. 각 한약제의 감마선 조사 시료는 3가지 시험 모두에서 비조사 시료와 유사한 효과를 나타내었으며(p<0.05), 생체내 독성도 나타내지 않았다. 이는 생약재의 여러 가지 고유 효능 중 일부의 안정성으르 확인한 것으로 생각되며, 이 결과로 미루어 보아 감마선 조사 생약재의 효능 안정성은 한의학적 고유의 효능 비교 평가를 통하여 확인될 수 있을 것으로 사료된다. 한편, 저자 등은 감마선 조사 생약재의 유효성분 안정성 및 유전 독성학적 안전성을 확인하여 보고한 바 있다. 이들 결과를 토대로 향후 감마선 조사 행약재의 고유 효능의 안정성에 관한 체계적인 연구결과를 얻는다면 생약재의 위생화 수단으로 감마선 조사기술의 이용이 실용화될 수 있을 것으로 사료된다.

Keywords

References

  1. Safety and nutritional adequacy of irradiated food WHO
  2. Wholesomeness of irradiated food Report of a joint FAO/IAEA/WHO expert committee on the wholesomeness of irradiated food WHO
  3. 36th General Conference of the International Atomic Energy Agency, Scientific session Food irradiation : The position of the World Health Organization Daferstein, F.K.
  4. Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Food irradiation :up-to-date status Ahmed, M.
  5. Chung-Kuo-Chung-His-I-Chieh-Ho-Tsa-Chih v.12 Immunological and hematopoietic effect of Codonopsis pilosula on cancer patients during radiotherapy Zneg, X.L.;Li, X.A.;Zhang, B.Y.
  6. Exp. Hematol. v.16 Radioprotection of hemopoiesis conferred by Acanthopanax senticosus Harms(Shigoka) administered before of after irradiation Miyanomae, T.;Frindel, E.
  7. Yakugaku Zasshi v.110 Studies on chemical protectors against radiation. XXX. Radioprotective substances of cnidii rhizoma Ohta, S.;Sakurai, N.;Sato, Y.;Inoue, T.;Shinoda, M.
  8. Am. J. CHin. Med. v.18 Radioprotective effect of Ganoderma lucidum(Leyss. Ex. Fr.) Karst after X-ray irradiation in mice Hsu, H.Y.;Lian, S.L.;Lin, C.C.
  9. Chung-Kuo-Chung-Yao-Tsa-Chih v.19 Effects of radix Astragali on hemopoiesis in irradiated mice Quan, H.X.;Li, H.S.
  10. Radiobiology for the Radiologist. 4th ed. Hall, E.J.
  11. Cancer Res. v.42 Protective effects of S-2-(3-aminopropylamino) ethylphosphorothioic acid against radiation damage of normal tissues and a fibrosarcoma in mice Milas, L.;Hunter, N.;Reid, B.O.;Thames, Jr.H.D.
  12. Pharmacol. Ther. v.39 Radioprotectors in tumor radiotherapy : Factors and settings determining therapeutic ratio Milas, L.;Murray, D.;Brock, W.A.;Meyn, R.E.
  13. J. Immunol. v.136 Interleukin 1 is a radioprotector Neta, R.;Douches, S.;Oppenheim, J.J.
  14. Pharmacol. Ther. v.39 Role of cytokines in radioprotection Neta, R.
  15. Int. J. Radiat. Biol. v.57 Therapeutic use of recombinant human G-CSF(rhG-CSF) in canine model of sublethal and lethal whole body irradiation MacVittie, T.J.;Monroy, R.L.;Patchen, M.L.;Souza,L.M.
  16. Am. J. Med. Sci. v.300 Hematoopoitic growth factors : Overview and clinical applications Robinson, B.E.;Quesenberry, P.S.
  17. Am. J. Chin. Med. v.27 Evaluation of radioprotective effects of two basic prescription of traditional Chinese medicine : Si-Wu-Tang and Si-Jun-Zi-Tang Lee, S.E.;Oh, H.;Yang, J.A.;Jo, S.K.;Byun, M.W.;Yee, S.T.;Kim, S.H.
  18. Korean J. Vet. Res. The radioprotective effects of Bu-Zhong-Yi-Qi-Tang as a prescriptions of traditional Chinese medicine in irradiated mice Kim, S.H.;Lee, S.E.;Oh, H.;Yang, J.A.;Jo, S.K.;Yu, Y.B.;Byun, M.W.;Yee, S.T.
  19. J. Korean Soc. Food Sci. Nutr. v.28 The radioprotective effects of Sam-Ryung-Baek-Chul-San(San-Ling-Bai-Shu-San) as a prescriptions of traditional Chinese medicine in irradiated mice Lee, S.E.;Oh, H.;Yang, J.A.;Jo, S.K.;Yu, Y.B.;Byun, M.W.;Kim, S.H.
  20. J. Ethnopharmacol. v.52 Protection of mouse bone marrow by si-wu-tang against whole body irradiation Hsu, H.Y.;Ho, Y.H.;Lin, C.C.
  21. The pharmacognostical therapy in treatment of blood stasis. Lin, C.C.
  22. Gan To Kagaku Ryoho v.12 Studies on the antitumor activity of traditional Chinese medicine Ito, H.;Shimura, K.
  23. Immunopharmacol. Immunotoxicol. v.14 Effect of the tradiational Chinese medicine, bu-zhong-yi-qi-tang(Japanese name : Hochu-ekki-to) on the protection against Listeria monocytogens infection in mice Li, X.Y.;Takimoto, H.;Miura, S.;Yoshikai, Y.;Matsuzaki, G.;Nomoto, L.
  24. Methods Find Exp. Clin. Phrmacol. v.20 Effect of Hochu-ekki-to, Yoku-kan-san and Saiko-ka-ryukotsu-borei-to on behavioral despair and acetic acid-induced writhing in mice Koshikawa, N.;Imai, T.;Takahashi, I.;Yamauchi, M.;Sawada, S.;Kansaku, A.
  25. Yakugaku Zasshi v.110 Protective activities of a Chinese medicine, Hochuekki-to, to impairment of hematopoietic organs and to microbiral infection Ikeda, S.;Kaneko, M.;Kumazawa, Y.;Nishimura, C.
  26. Hinyokika Kiyo v.34 Clinical effect of hotyuekkito(buzhongyiqitang) on symptoms due to renal ptosis and stress incontinence Murakami, Y.
  27. Am. J. Chin. Med. v.20 The hormonal response to HCG stimulation on patienets with male infertility before and after treatment with hochuekkito Ishikawa, H.;Manabe, F.;Zhongtao, H.;Yoshii, S.;Koiso, K.
  28. 한약조제 지침서 해설 한약위원회;조제지침연구소위원회
  29. 한약방제학 약대 한약학 교재연구회
  30. Int. J. Cancer v.62 Interleukin-11 protects the clogenic stem cell in murine small-intestinal crypts from impairment of their reproductive capacity by radiation Potten, C.S.
  31. Exp. Hematol. v.16 Radioprotection of hemopoiesis conferred by Acanthopanax senticosus Harms (Shigoka) administered before of after irradiation Miyanomae, T.;Frindel, E.
  32. J. Histochem. v.41 A new method to detect apoptosis in paraffin section : In situ end-labeling of fragmented DNA Wijsman, J.H.;Jonker, R.R.;Keijzer, R.;Van Velde, C.J.H.;Corneliess, C.J.;Van Dierendonck, J.H.
  33. Food Chem. Toxicol. v.31 Cell-cycle and ploidy analysis in bone marrow and liver cells of rats after long-term consumption of irradiated wheat Maier, P.;Wenk-Siefert, I.;Schawalder, H.P.;Zehnder, H.;Schlatter, J.
  34. Biomed. Environ. Sci. v.2 Safety evaluation of irradiated food in China : a condensed report Yin, D.
  35. Int. J. Rad. Appl. Instrum. A. v.38 Measurements of induced radioactivity in electron-and photon-irradiated beef Miller, A.;Jensen, P.H.
  36. Vopr. Pitan. v.4 Toxicological evaluation of gamma ray-treated fresh fish in an experiment on rats Shatrov, G.N.;Zaitsev, A.N.;Rakhmanina, N.L.;Kamal'dinova, Z.M.
  37. Toxicol. Eur. Res. v.5 Effects of irradiated wheat flour in the AKR mouse. III. Effects of activity of hepatic and pancreatic enzymes Delcour Firquet, M.P.
  38. Toxicol. Eur. Res. v.5 Effects of irradiated wheat flour in the AKR mouse. I. Effects of longevity, morbidity and pathology Delcour Firquet, M.P.
  39. Toxicol. Eur. Res. v.5 Effects of irradiated wheat flour in the AKR mouse. II. Effects of hematology and activity of serum enzyme Delcour Firquet, M.P.;Bruaux, P.
  40. Toxicol. Lett. v.7 Long-term feeding syudies in mice fed a diet containing irradiated fish. I. Multigeneration reproduction, mutagenicity, teratology, and longevity studies van Petten, L.E.;Calkins, J.E.;McConnel, R.F.;Gottschalk, H.M.;Elias, P.S.
  41. J. Korea Soc. Food Sci. Nutr. v.29 Stability in immunomodulation activity of irradiated Angelica gigas Nakai Jo, S.K.;Park, H.R.;Yu, Y.B.;Song, B.C.;Yee, S.T.
  42. Korean J. Food Sci. Technol. v.30 Effect of gamma irradiation on microbial decontamination, extraction yield and physiological effectiveness of Korean medicinal plants Yook, H.S.;Cha, B.S.;Jo, S.K.;Byun, M.W.
  43. J. Food Hyg. Safety v.11 Effect of gamma irradiation on the red ginseng powder Yook, H.S.;Kim, S.A.;Jo, S.K.;Byun, M.W.
  44. J. Korea Soc. Food Sci. Nutr. v.29 Evaluation on the safety of ？irradiation Angelica gigas Nakai : Stability of active components and safety in genotoxicity Yu, Y.B.;Jo, S.K.
  45. J. Food Hyg. Safety v.12 Genotoxicological safety of the gamma-irradiated medicinal herbs Jo, S.K.
  46. Food Addit. Contam. v.9 Food irradiation : is it an alternative to chemical preservatives? Diehl, J.F.
  47. Effect of gamma irradiation on the microbiological, biochemical, morphological, nutritional, toxicological and food processing characteristics of beef Yook, H.S.