Biotechnology and Bioprocess Engineering:BBE

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
권호 표지

DNA Chip Technologies

  • Hwang, Seoung-Yong (Department of Biochemistry and milecular Biology, Hanyang University, Ansan 425-791) ;
  • Lim, Geun-Bae (MEMS Lab., Samsung Abvanced Institute of Technology)
  • Published : 2000.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

The genome sequencing project has generated and will contitute to generate enormous amounts of sequence data. Since the first complete genome sequence of bacterium Haemophilus in fluenzae was published in 1995, the complete genome sequences of 2 eukaryotic and about 22 prokaryotic organisms have detemined. Given this everincreasing amounts of sequence information, new strategies are necessary to efficiently pursue the phase of the geome project- the elucidation of gene expression patterns and gene product function on a whole genome scale. In order to assign functional information to the genome sequence, DNA chip technology was developed to efficienfly identify the differential expression pattern of indepondent biogical samples. DNA chip provides a new tool for genome expreesion analysis that may revolutionize revolutionize many aspects of human kife including mew surg discovery and human disease diagnostics.

Keywords

References

  1. Science v.269 Whole-genome random sequencing and assembly of Haemorphilus influenzae Rd. Flischman, R. D.(et al.)
  3. Proc. Natl. Acad. Sci. USA 74 Method for detection of specific RNAs in agarose gels by transfer to diazobenzyoxymethyl-paper and hydridization with DNA probes Alwine, J. C.;D. J. Kemp;G. R. Stark
  4. Cell v.34 Idenification of two distint regulatory regions adjacent to the human β-interferon gene Zinn, K.;D. DiMaio;T. Maniatis
  5. Cell v.16 Isolation galactose-inducible DNA sequences from Saccharomyces cerevisiae by differential plaque filter hybridization John, T. P.;R. W. Davis
  6. Science v.270 Quantitative monitoring of gene expression patterns with a compementary DNA microarray Schena, M.;D. Shalon;R. W. Davis;P. O. Brown
  7. Korean Soc. Med. Biochem. Mol. Biol. News v.6 DNA chip technologies: Array of hope Hwang, S. Y.
  9. Nat. Genet. Suppl. v.21 Expressionprofiling using cDNA microarrays Duggan, D. J.;M. Bittner;Y. Chen;P. Meltzer;J. M. Trent
  11. DNA Microarrays Application of ink-jet printing technology to the manufacture of molecular arrays Theriault, T. P.;S. C. Winder;R. C. Gamble
  13. Korean Soc. Med. Biochem. Mol. Bio. News v.4 Whole genome analysis using DNA chips Hwang, S. Y.
  14. Nat. Genet. Supp. v.21 High density synthetic oligonucleotide arrays Lipshutz R. J.;S. P. A. Fodor;T. R. Gingeras;D. J. Lockhart
  15. Nat. Biotehcnol. v.17 Maskless fabrication of light-directed oligonucleotide microarrays using a digital micromirror array Singh-Gasson, S.;R. D. Green;Y. Yue;C. Nelson;F. Blattner;M. R. Sussman;F. Cerrina
  17. DNA Microarrays Active Microelectronic arrats for DNA hybridizationanalysis Heeler, M. J.;E. Tu;A. Holmsen;R. G. Sosnowski;J. O'connel
  18. Nat. Genet. Supp. v.21 DNA microarrays in drug discovery and development Debouck, C.;P. N. Goodfellow
  19. Nat. Genet. Supp. v.21 Gene Expression informatics - it's all in your mine Bassett Jr., D. E.;M. B. Eisen;M. S. Boguski