Journal of Life Science
- 제10권1호
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- Pages.37-39
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- 2000
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- 1229-1552(pISSN)
The Arg and Lys-Rich Motif in the TSPY Gene of Humans and Japanese Monkeys (Macaca fuscata) is Conserved in Various Primate Species
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Kim, Heui-Soo
(Corresponding author, Division of Biological Sciences, College of Natural Sciences, Pusan National University, Pusan 609-735) ;
- Takashi Kageyama (Department of Cellular and molecular Biology, Primate REsearch Institute, Kyoto University, Inuyama 484-8506, Japan) ;
- Osamu Takenaka (Department of Cellular and molecular Biology, Primate REsearch Institute, Kyoto University, Inuyama 484-8506, Japan)
- 발행 : 2000.04.01
초록
Testis-specific protein Y(TSPY) is thought to play an important role during spermatogenesis in primates. The Arg and Lys-rich region of TSPY was implicated as a potential DNA binding site in the human and Japanese monkey. In the study, we investigated this further through looking at the putative amino acid sequences of Arg and Lys-rich region of TSPY gene from seven species of gibbons, five species of Old World monkeys and five species of New World monkeys. A comparison with those of the human and Japanese monkey revealed that the Arg and Lys-rich motif was hightly conserved in various primates. This finding suggests that a possible role for the Arg and Lys-rich motif in primate TSPY is DNA recognition. The functional implications for TSPY are discussed in the light of this and previous findings.