대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

흰쥐의 뇌 Astrocyte에서 amyloid-${\beta}$ 25-35로 유발된 세포 독성과 지질과산화에 대한 호도(胡桃)의 보호효과

Protective effects of Juglandis semen on amyloid-${\beta}$-induced neuronal toxicity and lipid peroxidation in rat astrocytes

  • 장미경 (동국대학교 한의과대학 내과학교실) ;
  • 박종혁 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실) ;
  • 김철호 (동국대학교 한의과대학 생화학교실) ;
  • 윤철호 (동국대학교 한의과대학 내과학교실)
  • Jang, Mi-Kyung (Department of Internal Medicine, College of Orient Medicine, Dongguk University) ;
  • Park, Jong-Hyuck (Department of Internal Medicine, College of Orient Medicine, Dongguk University) ;
  • Jeong, Ji-Cheon (Department of Internal Medicine, College of Orient Medicine, Dongguk University) ;
  • Kim, Cheorl-Ho (Department of Biochemistry & Molecular Biology, College of Orient Medicine, Dongguk University) ;
  • Yoon, Cheol-Ho (Department of Internal Medicine, College of Orient Medicine, Dongguk University)
  • 발행 : 2000.10.30
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초록

호도(胡桃)(Juglandis semen)가 치매에 미치는 영향을 알아보기 위하여 치매(Alzheimer's disease) 유발물질로 알려진 amyloid-{$\beta}(A{\beta})$ 25-35를 흰쥐의 뇌 신경세포의 일종인 astrocyte에 처리한 후 뇌의 신경세포에 대한 독성 및 세포막에서의 지질 과산화에 미치는 영향을 검토하였다. 호도(胡桃)는 $A{\beta})$ 25-35로 인한 신경세포의 파괴를 억제하는 것으로 나타나 신경세포의 손상을 예방하고 보호하는 효과가 있었다. 그리고, 지질의 과산화 지표인 malondialdehyde 생성은 $A{\beta})$ 25-35 처리로 크게 증가하였으나, 호도(胡桃)의 전처리와 후처리로 크게 감소되어 호도(胡桃)가 세포막 파괴로 인한 뇌세포의 손상을 방지하는 것으로 나타났다. 이러한 결과들을 볼 때, 호도(胡桃)는 신경세포의 하나인 astrocyte에 대한 보호효과와 세포막에서 지질의 과산화를 저해 및 $A{\beta})$ 25-35 처리와 같은 치매 유발 독성에 대한 적응능력 향상을 통하여 뇌 신경세포를 보호하는 효과가 있음을 보여주는 것으로 노인성 치매 등의 임상적 응용에 그 효과가 기대된다.

키워드

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