Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Quantitative Determination of Ursolic acid from Prunellae Herba

하고초(夏枯草, Prunellae Herba)로부터 Ursolic acid의 함량 분석

  • Kim, Ju-Sun (Natural Products Research Institute, Seoul National University) ;
  • Lee, Kyong-Soon (Dept. of Pharmacy, Chung Buk National University) ;
  • Chang, Seung-Yeup (Natural Medicines Standardization Division, Korea Food and Drug Administration) ;
  • Won, Do-Hee (Natural Medicines Standardization Division, Korea Food and Drug Administration) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
  • Published : 2000.12.30
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Abstract

Ursolic acid was isolated from Prunellae Herba (Prunella vulgaris var. lilacina) and identified by direct comparison with an authentic sample. A method of analysis for the evaluation of ursolic acid was developed based on extraction of ground plant material, followed by quantitative determination using capillary gas chromatography of the TMS derivative. Quantitative analysis by GC after derivatisation under mild silylating conditions showed 0.31% ursolic acid in 20 samples collected throughout regions of Korea while no ursolic acid was detected in the samples of the whole plant of Thesium chinense, a substitute for Prunellae Herba in southern regions of Korean peninsula.

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