사상체질의학회지 (Journal of Sasang Constitutional Medicine)

  • 제12권2호
  • /
  • Pages.171-183
  • /
  • 2000
  • /
  • 1226-4075(pISSN)
  • /
  • 2287-786X(eISSN)
사상체질의학회 (The Society Of Sasang Constitutional Medicine)
권호 표지

목단피지황탕(牧丹皮地黃湯)이 위점막손상(胃粘膜損傷)에 미치는 영향(影響)

Effects of Mokdanpijihwang-tang on gastric mucosal damage in mice

  • 박성식 (동국대학교 한의과대학 사상체질과) ;
  • 이지영 (동국대학교 한의과대학 사상체질과)
  • Park, Seong-Sik (Department of Sasang Constitution Medicine, College of Orient Medicine, Dongguk University.) ;
  • Lee, Ji-Young (Department of Sasang Constitution Medicine, College of Orient Medicine, Dongguk University.)
  • 발행 : 2000.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

1. Back ground and purpose An experimental study has done to examine the effect of defense and cure gastric mucasal damage of Mokdan-pijihwang-tang. 2. Methods Mice had intragastric injected with MJ extract before indomethacin treatment which induces homorrhage infarct and erosion artificially. Degree of lipid peroxidation, general morphology, change of mucous cell, the distribution of PNA, ICAM and distribution of apoptotic cell were objected. (Abbreviation) MJ : Mokdanpijihwang-tang, PNA : Peanut Agglutinin, ICAM : Intercellular Adhesion Molecule 3 Results 1) The degree of lipid peroxidation in INDO-group had increased conspicuously than control group. But the degree of lipid peroxidation in MJ-group had decreased than INDO-group and these decline had probability. 2) After indomethacin treatment, hemorrhage infarct and erosion had increased in stomach body. But in MJ-group, the configuration is normal, except the group intragastric injected with MJ extract at hour 24 before indomethacin treatment. 3) Surface mucous cell and neck mucous had disappeared in INDO-group. But in MJ-group tormal distribution had shown like control group except the group intragastric injected with MJ extract at hour 24 before indomethacin treatment. 4) PNA positive reaction had not shown in INDO-group. But medium PNA positive reaction had shown In Mj-group. 5) ICAM positive reacted cell had shown in INDO-group. The decrease of ICAM positive cell were shown than INDO-group. 6) A number of apoptotic cell was distributed in hemorrhagic erosion. A few number of apoptotic cell was distributed in MJ-group except some surface mucous. 4. Conclusion These results suggest that MJ has an effect on cure of gastric mucosal damage.

키워드

참고문헌

  1. 四象醫學 宋一炳(外)
  2. 사상의학회지 v.7 no.1 四象方劑構成의 分析硏究 趙晃盛
  3. 詳校顯吐 東醫壽世保元 全 尹完重
  4. 東醫四象要訣 朴寅商
  5. 四象新編 元持常
  6. 東醫四象處方集 廉秦煥
  7. 東醫四象診療醫典 李泰造
  8. 朝醫學 朝鮮醫學硏究所編
  9. 朝鮮民族四象醫學 張文宣(외)
  10. 상지대학교 석사학위논문 蔘朮健脾湯이 胃腸 및 中樞神經系에 미치는 影響 金太均
  11. 상지대학교 석사학위논문 三黃枳朮丸의 潰瘍 抑制 效能에 關한 實驗的 硏究 鄭載淑
  12. 경산대학교 석사학위논문 平陳健脾湯이 白鼠의 alcohol性 胃潰瘍에 미치는 影響 金南希
  13. 동의대학교 석사학위논문 加味歸脾湯이 흰쥐의 胃潰瘍에 미치는 影響 白東鎭
  14. 경희대학교 석사학위논문 침자극과 丹蔘投與가 胃潰瘍에 미치는 影響 朱貞柱
  15. 경희대학교 박사학위논문 手拈散이 胃潰瘍 및 鎭痛에 미치는 影響 金英俊
  16. 원광대학교 석사학위논문 桂枝加龍骨牡蠣湯 엑기스가 實驗的 胃潰瘍에 미치는 影響 金德宗
  17. 경희대학교 석사학위논문 滋陰健脾湯이 구속스트레스 흰쥐의 胃潰瘍 및 血中 Catecholamine含量에 미치는 影響 姜賢根
  18. 동국대학교 석사학위논문 淸熱解鬱湯이 흰쥐의 實驗的 胃潰瘍에 미치는 影響 金常國
  19. 경희대학교 석사학위논문 六鬱湯이 구속스트레스 흰쥐의 胃潰瘍 및 血中 Catecholamine含量에 미치는 影響 趙英度
  20. 원광대학교 석사학위논문 增味二陳湯 엑기스가 實驗的 胃潰瘍에 미치는 影響 李長泉
  21. 경희대학교 석사학위논문 補血安神湯이 구속스트레스 흰쥐의 血中 Catecholamine含量에 미치는 影響 金永源
  22. 동국대학교 석사학위논문 越鞠丸과 七氣湯이 白鼠의 實驗的 胃潰瘍에 미치는 影響 文相元
  23. 상지대학교석사학위논문 大建中湯의 抗潰瘍 및 胃腸管에 미치는 效果에 關한 實驗的 硏究 金革圭
  24. 상지대학교 석사학위논문 半夏枳朮丸의 效能에 關한 實驗的 硏究 金蕙英
  25. 사상의학회지 v.9 no.2 獨活地黃湯의 胃腸管 및 中樞神經에 미치는 效能에 關한 實驗的 硏究 陣鉉喆
  26. 사상의학회지 v.9 no.2 太陰調胃湯의 潰瘍抑制 效能에 關한 硏究 朴東彦
  27. 경산대학교 석사학위논문 桃化湯이 白鼠의 消化性 潰瘍 및 腸管輸送能에 미치는 影響 李益行
  28. 동국대학교 석사학위논문 寶豆甘草末 抽出物이 흰쥐의 消化性 潰瘍에 미치는 影響 鄭周和
  29. 圓光大學校 碩士學位論文 雙金湯 엑기스가 實驗的 急性 胃淡 및 胃潰瘍에 미치는 影響 이상헌
  30. 경희대학교 박사학위논문 少陽人 荊防地黃湯 十二味地黃湯과 少陰人 補中益氣湯 十全大補湯의 免疫反應에 關한 實驗的 硏究 張賢鎭
  31. 경희대학교 석사학위논문 少陽人 荊防地黃湯의 效能에 關한 實驗的 硏究 金達來
  32. 경희대학교 박사학위논문 少陰人補中益氣湯 및 十全大補湯과 少陰人 荊防地黃湯 및 十二味地黃湯이 甲狀腺 機能亢進症에 미치는 影響에 關한 實驗的 硏究 趙晃晟
  33. 경희대학교 석사학위논문 荊防地黃湯이 抗 스트레스효과에 關한 實驗的 硏究 洪永旭
  34. 경희대학교 박사학위논문 荊防地黃湯이 alzheimer's disease 모델 白鼠의 學習과 記憶에 미치는 影響 趙潤淑
  35. 경희대학교 석사학위논문 荊防地黃湯이 흰쥐의 morris 水中 迷路學習과 記憶에 미치는 影響 李在爀
  36. Anal Biochem. v.95 Assay for lipid peroxide in animal tissue by thiobar- bituric acid reaction Ohkawa, H.;Ohishi, N.;Yaki, K.
  37. 사상의학회지 v.7 no.1 荊防地黃湯 硏究 全炳烈;金光澤;林長靑;整理
  38. 實用中西醫結合診療治療學 陳其遠;楊恩樹
  39. 胃腸病百科 v.17 柳東俊(外)
  40. Role of neutrophil-mediated inflammation in aspirin-induced gastric mucosal injury Norimasa Yoshida, M.D.;Toshikazu Yoshikawa, M.D.;Yasunari Nakamura, M.D.(et al.)
  41. Experimental gastric mucosal injury: laboratory molels reveal mechanism of pathogenesis and new therapeutic strategies Gary, B. Glavin;Sandor Szabo
  42. Ethnopharmacology Gastric antiulcer and cytoprotective effect of Commiphora molmol in rats AI-Harbi, M.M.;Qureshi, S.;Raza, M.;Ahmed, M.M.;Afzal, M.;Shah, A.H.
  43. British Journal of Rheumatology Epidemiology and prevention of non-steroidal anti- inflammatory drug effects in the gastrointestinal tract Agrawal, N.M.
  44. The pharmacological differences and sinilarities between stress and ethanol-induced gastric mucosal damage Cho, Chi-Hin;Clive W. Ogle
  45. The celluler and molecular basis of gastric mucosal defense John L. Wallace;Nell Granger, D.
  46. 原色最新醫療大百科辭典 新太陽社 編輯局 白科事典部
  47. Biology and toxic dffects of nonsteroidal anti- inflammatory drugs Lee, S.;Simon, M.D.
  48. NSAID-induced gastroduodenal damage: is prevention needed? Ruth Stalnikowicz, M.D.;Daniel Rachmilewitz
  49. Prostaglandins in the stomach: an update Tetsuo Arakawa, M.D.;Kazuhide Higuchi, M.D.;Takashi Fukuda, M.D.(et al.)
  50. Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation Inoue, K.;Motonaga, A.;Dainaka, J.(et al.)
  51. Protective effects of prostaglandins against ulcerogenic activity of indomethacin during different stages of erosion development in rat stomach VAN Kolfschoten, A.A.;Hagelen, F.;Hillen, F.C.;Jager, L.P.;Zandberg, P.;VAN Noordwijk, J.
  52. Gen. Pharmac v.4 Nitric oxide, prostaglandin and sensory neurons in gastric mucosal blood flow response during acid secretion in rats Shinichi Kato;Takuya Hirata;Koji Takeuchi
  53. Digestive Diseases and Sciences v.12 Inhibition of gastric motor activity by 16, 16-dimethyl prostaglandin E2(a possible explanation of cytoprotection) Koji Takeuchi;Youichi Nobuhara
  54. Charlotte Soderman and Elvar Theodorsson. Indomethacin influences regulatory peptides and increases DNA synthesis in the gastrointestinal tract of the rat. ISSN Andres Uribe;Marjo Kapraali;Mahbulb Alam
  55. Digestive Diseases and Sciences v.31 no.10 Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats Koji Takeuchi;Shigeru Ueki;Susumu Okabe
  56. Indomethacin and turnover of fastric mucosal cell in the rat Baumgarner, A.;Koelz, H.R.;Halter, F.