Korean Journal of Head & Neck Oncology (대한두경부종양학회지)
- Volume 15 Issue 1
- /
- Pages.29-34
- /
- 1999
- /
- 1229-5183(pISSN)
- /
- 2586-2553(eISSN)
Extramedullary Plasmacytoma of the Head and Neck
두경부 골수외 형질세포종의 임상적 고찰
- Shim Kwang-Yong (Department of Internal Medicine, Yonsei University College of Medicine) ;
-
Ahn Joong-Bae
(Department of Internal Medicine, Yonsei University College of Medicine) ;
- Kim Gwi-Eon (Department of Internal Medicine, Yonsei University College of Medicine) ;
-
Chung Hyun-Cheol
(Department of Internal Medicine, Yonsei University College of Medicine) ;
-
Kim Joo-Hang
(Department of Internal Medicine, Yonsei University College of Medicine) ;
- Kim Byung-Soo (Department of Internal Medicine, Yonsei University College of Medicine) ;
- Roh Jae-Kyung (Department of Internal Medicine, Yonsei University College of Medicine)
- 심광용 (연세대학교 의과대학 내과학교실) ;
-
안중배
(연세대학교 의과대학 내과학교실) ;
- 김귀언 (연세대학교 의과대학 내과학교실) ;
-
정현철
(연세대학교 의과대학 내과학교실) ;
-
김주항
(연세대학교 의과대학 내과학교실) ;
- 김병수 (연세대학교 의과대학 내과학교실) ;
- 노재경 (연세대학교 의과대학 내과학교실)
- Published : 1999.05.01
Abstract
Objectives: This study was carried out to analyze the clinical profile and the results of treatment of a series of patients with extramedullary plasmacytoma(EMP) of the head and neck. Materials and Methods: The clinical features, treatment and survival of 14 patients with EMP seen at Yonsei Medical Center between 1970 and 1998 were carefully reviewed. Results: The median age was 48 years(range 15-75) and there was a male predominance(M:F 1.8:1). Nasal cavities and paranasal sinuses account for 50% of the primary sites and the most common symptom was airway obstruction(50%). Five patients(36%) showed evidence of adjacent bone destruction, one patient had lymph node involvement and one patient had an IgG monoclonal gammopathy at the time of diagnosis. All 5 patients treated with radiotherapy alone achieved local control. Of 5 patients treated with surgery alone, 2 patients(40%) had local failure. Of 3 patient treated with a combination of surgery and radiotherapy, one patient had local recurrence. A total of7 patients(54%) had local, distant or nodal relapses after primary treatment. Six of them received salvage treatment. With salvage treatment of surgery and/or radiotherapy, local control was achieved in 4 of 6 patients. Conversion to multiple myeloma was seen in one patient. Conclusion: Radiotherapy should be recommanded as treatment of choice for EMP of the head and neck. Surgery should be reserved for radioresistant or recurrent tumors, but tumors that are localized and can be removed relatively easily with little morbidity may be treated by primary surgery.