Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effects of Chrysanthemum Extract Drinks on Sociopsychological Stress

사회.심리적 스트레스에 미치는 국화 추출 음료의 영향

  • 최진호 (부경대학교 식품생명공학부 생화학연구실) ;
  • 김대익 (부경대학교 식품생명공학부 생화학연구실) ;
  • 박수현 (부경대학교 식품생명공학부 생화학연구실) ;
  • 김동우 (부경대학교 식품생명공학부 생화학연구실) ;
  • 조원기 (조아제약(주)) ;
  • 유병팔 (텍사스대학교 의과대학 생리학과)
  • Published : 1999.10.01
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Abstract

The effects of anti-stress chrysanthemum flower (ASCF) extract drink (ASCF-0.1% and ASCF-0.5% concentrations) were tested for the anti-stress action. ICR male mice (20$\pm$2 g) were fed with basic experimental diets and given free access to water containing these ingredients for 18 days. Psychological stress/sociopsychologcal stress exposed by foot-shock for 1 hour for 3 days. Both ASCF-0.1 and ASCF-0.5 groups in the sociopsychological stress resulted in a significant decrease of 28.1% and 27.3% in plasma corticosterone (CS) secretion compared with psychological stress (control group). Noradrenaline (NA) secretions in the brain were significantly increased 49.7% and 53.9%, respectively, in ASCF-0.1 and ASCF-0.5 groups compared with control group. MHPG-SO4 (3-Methoxy-4-hydroxyphenylethy-leneglycol sulfate) levels in the brain resulted in a marked decreases of 12.9% and 16.6%, respectively in ASCF-0.1 and ASCF-0.5 groups. NA/MHPG-SO4 ratios in the brain of ASCF-0.1 and ASCF-0.5 groups resulted in a significantly increase of 71.3% and 81.0%, respectively, compared with control group. These results suggest that anti-stress chrysanthemum flower (ASCF) drink can effectively ridded the sociopsychological stress.

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References

  1. J. Phychait, Res. v.4 Brain amines and emotional stress Bliss, E.L.;Zwanziger,J.
  2. J. Pharmac. Exp. Ther. v.164 Metabolism of norepinephrine, serotonin and dopamine in rat brain with stress Bliss, E.L.;Ailion, J.;Zawanziger,J.
  3. Bodily changes in pain, hunger, fear and rage(2nd ed.) Cannon, W.B.
  4. Br. J. Pharmac. v.51 Studies on the metabolism of catecholamines in the central nervous system of the mouse Ceasar, P.M.;Hague,P.;Sharman, D.F.;Wwrdinius, B.
  5. Korean J. Life Science v.9 no.5 Effects of seatangle (Laminaria japonica) and fucoidan components on sociopsychological stress Choi, J.H.;Kim. D.I.;Park, S.H.;Kim. D.W.;Lee, J.S.;Ryu,J.H.;Chung, Y.S.
  6. Korean J. Life Science v.9 no.5 Effects of mind tonic drink on sociopsychological stress Choi, J.H;Kim, D.I.;Park,S.H.;Kim. D.W.;Cho, W.K.;Yu. B.P.
  7. Life Sci. v.7 The effect of immobilization stress on the activity of central monoamine neurons Corrodi, H.;Fuxe, K.;Hokfelt, T.
  8. Pharm. Biochem. & Behavior v.16 Physiological stress enhances noradrenaline turnover in specific brain regions in rats Imori, K.;Tanaka, M.;Kohno,Y.;Ida, Y.;Nakagawa, R.;Hoaki, Y.;Tsuda, A.;Nagasawa, N.
  9. Anal. Biochem. v.97 Simultaneous determination of noradrenaline and 3-methoxy-4-hydroxy-pheny-lethylene-glycol sulfate in descrete brain regions of the rat Kohno, Y.;Matsuo, K.;Tanaka,M.;Furukawa, T.;Nagasaki, N.
  10. J. Neurochem. v.36 Regional distribution and production rate of 3-methoxy-4-hydroxyphenyl-ethy-leneglycol sulfate (MHPG-SO₄) in rat brain Kohno, Y.;Matsuo, K.;Tanaka, M.;Furukawa, T.;Nagasaki, N.
  11. Eur.J. Pharmac. v.21 Stimulation and destruction of the locus coeruleus;Opposite effcts on 3-methyl-4-hydroxyphenylethy-leneglycol sulfate levels in the rat cerebral crotex Korf, J.;Agahjanian, G.K.;Roth, R.H.
  12. J. Pharmac. Exp. Ther. v.143 Stress-induced release of brain norepinephrine and its inhibition by druges Maynert, E.W.;Levi, R.
  13. Pharmac. Biochem. Behav, v.14 Regional responese of rat brain noradrenergic neurons to acute intense stress Nakasawa, R.;Tanaka, M.;Kohno, Y.;Noda, Y.;Nagasaki, N.
  14. Jpn, J. Psychosom. Med. v.6 Psychophysiology of emotion-communication of emotion Ogawa, N.;Kuwahara, K.
  15. Brain Res. v.152 Magnitude of stressinduced brain norepinephrine depletion varies with age Ritter, S.;Pelzer, N.L.
  16. Endocrinology and Metabolic Clinics v.16 no.4 Stress and Glucocoticonoids in Aging Sapolsky, R.;Armanini,M.
  17. Can. Med. Assoc. J. v.34 The alarm reaction Selye, H.
  18. Can. Med. Assoc. J. v.115 Forty yearsof stress reseach;Principal remaining problems and misconceptions Selye, H.
  19. Brain Res. v.618 Psychological stress increases arousal through brain corticotropin-releasing hormone without significant increase in adrenocorticortopin and catecholamine secretion Shibasaki, T.;Imaki, T.;Hotta, M.;Ling,N.;Demura, H.
  20. Clin, Chem. v.4 no.4 Practical procedure for estimation of corticosterone or hydrocotricortisoe Sliber, R.H.;Busch, R.D.;Oslapas, R.
  21. Catecholamines and Behavior v.2 Sterss and catecholamines Stone, E.A.;A.J. Friedhoff(ed.)
  22. J. Pharmac. Exp. Ther. v.163 Effects of stress on the metabolism of norepinephrine,dopamine and serotonin in the central nervous system of the rat. l. Modification of morepinephrine turnover Thierry, A.M.;Jovey, F.;Glowinski,J.;Kety, S.S.
  23. Acta, Endoc, v.38 Individual determianation of cortisol and corticoterone ina small sample of Peripheral blood Van del Vies, J.
  24. Br. J. Pharmac. v.60 The effects of ether stress of betametasone treament on the cocentrations of noradrenaline and dopamine in various regions of the rat brain Vellucci, S.V.
  25. 특허출원 제98-05862호 (1998.2.24) 마인드토닉을 이용한 기능성 스트레스 해소음료의 개발 최진호;조원기;유병팔
  26. 특허출원 제98-40338호 (1998.9.28) 장미 추출물을 이용한 기능성 스트레스 해소음료 최진호;조원기;김동우
  27. 특허출원 제98-05863호 국화 추출물을 이용한 기능성 스트레스 해소음료 최진호; 조원기;유병팔
  28. 특허 출원 제99-35525호 다시마와 후코이단을 함유한 스트레스 해소음료의 개발 최진호;김재윤
  29. 原色和漢圖鑑 v.下 難波恒雄(著)
  30. 日藥理誌 v.102 動物實驗におけるストレス負荷法 田中 正敏