Bactericidal Activities of DW-116, a New Quinolone

새로운 퀴놀론 항균제 DW-116의 살균 작용

  • Published : 1999.02.01

Abstract

The bactericidal activities of DW-116, a new fluoroquinolone was estimated by comparing the minimal bactericidal concentrations (MBCs) of it against some Gram-positive and -negative bacterial strains with the minimal inhibitory concentrations (MICs). The MBCs against the test organisms were equal to or two times higher than MICs. The results support that the antibacterial activity of DW-116 is bactericidal.

Keywords

References

  1. Quinolone antimicrobial agents(2nd ed.) In vitro activity of the quinolones Eliopoulos, G. M.;Eliopoulos, C. T.;Hooper D.C.(ed.);Wolfson J.S.(ed.)
  2. Agents Chemother v.41 In vitro and in vivo antibacterial efficacies of CFC-222, a new fluoroquinolone Kim, J. H.;Kang, J. A.;Kim, Y. G.;Kim, J. W.;Lee, J. H.;Choi, E. C.;Kim, B. K.
  3. Drugs v.49 no.SUP. 2 Quinolone mode of action Hooper, D. C.
  4. USA Patent No. 5496947-A.6 Novel quinolone carboxylic acid derivatives Yoon, S. J.;Chung, Y. H.;Lee, C. W.;Oh, Y. S.;Choi, D. R.;Kim, N. D.
  5. Program and Abstracts of the 35th Interscienc Conference on Antimicrobial Agents and Chemotherapy, San Francisco, 1995. abstract F196 The pharmacokinetic studies of DW-116 Lee, W. Y.;Hwang, Y. H.;Sung, S. K.;Moon, E. Y.;Chung, S. J.;Lee, D. K.
  6. Methods for Dilution antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically-third edition;approved standard M7-A3 National Committee for Clinical Laboratory Standards
  7. Antimicrob. Agents Chemother. v.38 In vitro antibacterial activity of AM-1155, a novel 6-fluoro-8-methoxy quinolone Wakabayashi, E.;Mitsuhashi, S.