YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Phototoxic Potential Mechanism of Pefloxacin Irradiated by UVB

UVB 조사에 의한 페플록사신의 광독성 유발 기전

  • 최윤수 (대구효성가톨릭대학교 약학대학) ;
  • 이경선 (영남대학교 약학대학)
  • Published : 1999.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

The effect of antioxidants on photochemical reaction of pefloxacin by UVB (290~320 nm) was investigated and the possible mechanism of phototoxicity on the skin was also studied. The photo-degradation of pefloxacin by UVB was suppressed by cysteine, reduced glutathione and ascorbic acid, but was promoted by ${\alpha}-tocopherol$. Squalene, accounts for more than 10% of skin surface lipids, was peroxidized by pefloxacin through both radical and singlet oxygen mechanism.

Keywords

References

  1. Research Bulletins of Catholic University of Taegu-Hyosung v.51 Studies on the photodegradation of pefloxacin II-Discussion on the kinetics of the photodegradation of Pefloxacin Choi, Y.;Lee, K.
  2. Antimicrob. Agents Chemother. v.36 no.8 Photostability and biological activity of fluoroquinolones subsituted at the 8 position after UV irradiation Matsumoto, M.(et al.)
  3. Therapie v.40 Tolerance of pefloxacin in the treatment of thirty six bone and joint infections Lopitaux, R.;Hermet, R.;Sirot, J.;Filiu, P.;Terver, S.
  4. Methods in Enzymology v.LII Microsomal lipid peroxidation. Biomembranes C Buege, J. A.;Aust, S. D.;Fleischer S.(ed.);Packer L.(ed.)
  5. The Science of Photobiology Kendric, C. S.
  6. J. A. C. S. v.94 no.3 Deuterium effects on singlet oxygen life-times in solutions. A new test of singlet oxygen reactions Merkel, P. B.;Nilsson, R.;Kearns, R.
  7. J. Chem. Soc. Perkin Trans. v.Ⅱ Thiyl free radicals : Direct observation of electron transfer reactions with phenothiazines and ascorbate Forni, L. G.;M nig. J.;Mora-arellano, V. O.;Willson, R. L.
  8. Photochem. Photobiol. v.50 no.3 Molecular mechanism of drug photosensitization-Ⅱ. Photohemolysis sensitized by ketoprofen Costanzo, L.;De Guidorell, G.;Cambria, A.;Fama, M.
  9. J. Pharm. Sci. v.81 no.4 Photodegradation of nifedipine under aerobic conditions : Evidence of formation of singlet oxygen and radical intermediate Vargas, F.;Rivas, C.;Machado, R.
  10. Science v.162 Mechanisms of photosensitized oxidation Foote, C. S.
  11. Eur. J. Biochem. v.174 The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E Wefers, H.;Sies, H.
  12. J. A. C. S. v.102 no.13 Does superoxide ion oxidize catechol, α-tocopherol, and ascorbic acid by direct electron transfer? Nanni, Jr. E. J.;Stallings, M.D.;Sawyer, D.T.
  13. Biochem. Pharmacol. v.49 no.10 Antioxidant characterization Halliwell, B.
  14. Proc. Natl. Acad. Sci. v.85 Antioxidant defenses and lipid peroxidation in human blood plasma Frei, B.;Stocker, K.;Ames, B. N.
  15. Arch. Biochem. Biophys. v.226 no.1 Oxidation of α-tocopherol in micelles and liposomes by the hydroxyl, perhydroxyl, and superoxide free radicals Fukuzawa, K.;Gebicki, J. M.
  16. Lipids v.21 no.4 The peroxidazing effect of α-tocopherol on autoxidation of methyl linolate in bulk phase Terao, J.;Matsushita, S.
  17. J. A. C. S. v.115 Tocopherol-mediated peroxidation. The prooxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein Bowry, V. W.;Stocker, R.
  18. Photodermatol. Photoimmunol. Photomed. v.10 In vitro phototoxic activities of new quinolone antibacterial agents : lipid peroxidative potentials Fujita, H.;Matsuo, I.
  19. Photochem. Photobiol. v.49 no.5 Production of malonaldehyde from squalene, a major skin surface lipid, during UV-irradiation Dennis, K. J.;Shibamoto, T.
  20. J. Invest. Dermatol. v.87 Lipid peroxidative potency of photosensitized thiazide diuretics Matsuo, I.;Fujita, H.;Hayakawa, K.;Ohkido, M.
  21. Arch. Dermatol. Res. v.278 Chlorpromazine-sensitized photooxidation of squalene Fujita, H.;Matsuo, I.;Okazaki, M.;Yoshino, K.;Ohkido, M.