Archives of Pharmacal Research
- Volume 22 Issue 4
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- Pages.417-422
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- 1999
- /
- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Two New Lignans from Lindera obtusiloba Blume
- Kwon, Hak-Cheol (Natural Products Laboratory, College of Pharmacy, Sung Kyun Kwan University) ;
-
Choi, Sang-Un
(Korea Research Institute of Chemical Technology)
;
-
Lee, Jung-Ock
(Korea Research Institute of Chemical Technology)
;
- Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
- Zee, Ok-Pyo (Natural Products Laboratory, College of Pharmacy, Sung Kyun Kwan University) ;
- Lee, Kang-Ro (Natural Products Laboratory, College of Pharmacy, Sung Kyun Kwna University)
- Published : 1999.08.01
Abstract
Two new furanolignans (3, 5), together with three known lignans (1, 2, 4,), were isolated from the stem of Lindera obtusiloba (Lauraceae). The structures of the compounds were determined as actifolin (1), pluviatilol (2), 5,6-dihydroxymatairesinol (3), (+)-syringaresinol (4), and $(+)-9^{l}$-O-trans-feruloyl-5,51-dimethoxylariciresinol (5) on the basis of physicochemical and spectroscopic evidences. Compounds 1, 2, 3, and 5 showed cytotoxicity against a small panel of human tumor cell lines with