The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

Effects of Cervus elaphus Acua-Acupuncture's solution on damage of Rat's Kidney induced by Ischemia and Reflow

녹용(鹿茸) 약침액(藥針液)이 허혈(虛血)후 재관류(再貫流)에 의한 신장(腎臟) 조직(組織) 손상(損傷)에 미치는 영향(影響)

  • Yoon, Cheol-Ho (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Jeong, Ji-Cheon (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Shin, Uk-Seob (Dept. of Pharmacy, Dongguk Medical Center)
  • 윤철호 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실) ;
  • 신억섭 (동국대학교 의료원 약제과)
  • Published : 1999.09.29
Download PDF
⟨ Previous Next ⟩

Abstract

Cervus elaphus (CE), being known to reinforce Kidney, have tested to study the effects concerning damages of renal tissue induced by oxygen free radicals. I had observed the effects of CE extract on damages of rat's kidney following ischemia and reflow. Before ischemia was caused, CE extract was applied $0.2m{\ell}$ per 250g through femoral vein in ischemia and reflow group and normal sailine was applied in normal group, Ischemia was caused by renal artery's clamp for 60 min and reflowed by clamp remove after 30 min. It was increased on the content of lipid peroxidation, activies and type conversion ratio of xanthine oxidase following ischemia and reflow. by clamp remove after 30 min. It was increased on the content of lipid peroxidation, activies and type conversion ratio of xanthine oxidase following ischemia and reflow. However, they were decreased when CE extract was pre-applied. Glutathione level was decreased in ischemia and reflow group, and increased in CE extract's pre-applied group. However, it could not seen special changes on aldehyde oxidase activities, either. In conclusion, CE extract recovers the damage of kidney due to ischemia and reflow by decreasing the lipid peroxidation.

Keywords

References

  1. 中醫雜誌 v.30 no.4 腎虛與超양化物岐化매關系初探 陳晏珍;江家貴;楊宏德
  2. 中西醫結合雜誌 v.10 no.7 保腎丸結合辨證治療對腎炎患者LPO水平的影響 鄒燕勤;章永紅;余承惠;陸念祖;陳正芳;蔡新;孫偉;仇正南;徐國平
  3. 湖北中醫雜志 v.17 no.6 20種補益中藥對양自由基淸除作用的硏究 羅佩卓;진漢深;龍盛京
  4. 山東中醫學院學報 v.15 no.3 27種中藥及SOD對體外大白鼠賂均漿過양化脂質生成的 影響 舒守琴;余美娟;李祝;姚曉유;周恩萍
  5. 原本編註醫學入門(上) 李천
  6. 朝鮮大醫大論文集 v.18 no.1 백서에서 신 허혈성 손상에 미치는 칼슘 길항제의 효과 문철웅;정종훈;박찬국;이승일;배학연;장경식;김만우;정춘해;홍순표;이병래;김호중
  7. 朝醫大論文集 v.16 no.2 Alterations of O2 metabolite scavengers and production of superoxide radicals in ischemic rat kidney Kim Myoung-Choel;Lee Byoung-Rai
  8. Transplant. Proc. v.17 no.1 Five-hour hypothermic lung preservation with oxygen free radical scavengers Stuart, R.S.;Baumgartner, W.A.;Borkon, A.M.;Bulkley, G.B.;Brown, J.D.;DelaMonte, S.M.;Hutchins, G.M.;Reitz, B.A.
  9. Transplant Proc. v.14 no.1 Effect of xanthine oxidase inhibition on renal circulation after ischemia Hansson, R.;Gustafsson, B.;Jonsson, O.;Lundstam, S.;Pettersson, S.;Schersten, T.;Waldenstrom, J.
  10. Free radical scavengers. J. Vasc. Surg. v.2 no.1 Protection of the kidney after temporary ischemia Ouriel, K.;Smedira, N.G.;Ricotta, J.J.
  11. Role of superoxide radicals. Gastroenterology v.82 no.1 Ischemic injury to the cat small intestine Parks, D.A.;Burkley, G.B.;Granger, D.N.;Hamilton, S.R.;McCord, J.M.
  12. Oxygen radicals and human disease. Ann. Intern. Med. v.107 no.4 Cross, C.E.;Halliwell, B.;Borish, E.T.;Pryor, W.A.;Ames, B.N.;Saul, R.L.;McCord, J.M.;Harman, D.
  13. J. Pharm. pharmacol. v.41 Mechanistic toxicology: A radical perspective David, R.
  14. FASEB.J. v.1 Oxidantsandhuman disease : Somenewconcepts Barry, H
  15. J. Biol. Chem. v.245 A mechanism for the production of ethylenefrom methional : Thegenerationofthe-hydroxyl radical by xanthine oxidase Beauchamp, C.;Fridovich, I.
  16. Comp. Biochem. Physiol. v.49B A Comparison of the distribution and electron accepor specificities of xanthine oxidase and aldehyde oxidase Kreintsky, T.A.;Tuttle, J.V.;Cattau, E.L.;Wang, P.
  17. Science v.185 Freeradicalandinflammation :Protectionof synovialfluidbysuper oxidedismutase McCord, J.M.
  18. FEBS Lett. v.32 Glutathiond peroxidase : A selenoenzyme Froh, L.;Gunzler, W.A.;Schock, H.H.
  19. Robbins pathologic basis of disease Ramzi, S.C.;Vinay, K.;Stanley, L.R.
  20. 神農本草經輯注 馬繼與(主編)
  21. 中華人民共和國藥典一九八五年版一部 中華人民共和國衛生部藥典委員會(編)
  22. 中草藥注射劑 錢百炎;願茂瑜;王成榮
  23. J. Biol. Chem. v.237 Hepatical dehyde oxidase.I. Purificationandproperties Rajagopalan, K.V.;Fridovich, I.;Handler, P.
  24. J. Biol. Chem. v.244 Theregulationofratliver xanthineoxidase:Conversionin vitroof the enzyme activity fromdehydrogenase (type D) to oxidase (type O) Stirpe, F.;DellaCorte, E.
  25. Anal. Biochem. v.95 Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction Ohkawa, H.;Ohishi, N.;Yaki, K.
  26. Arch. Biochem. Biophys. v.82 Tissue sulfhydryl group Ellman, G.L.
  27. J. Biol. Chem. v.193 Proteinmea surementwithfolin phenol reagent Lowry, O.H.;Rosebrough, N.J.;Farr, A.L.;Randall, R.J.
  28. Arch. Biochem. Biophys. v.250 no.1 Regulation of the mitochondrial ATP synthesis/ATPase complex Schwerzmann, K.;Pederson, P.L.
  29. Biochem. J. Milk xanthine oxidase type D(dehydrogenase) and type O(oxidase) : Purification and interconversion and some properties Batteli, N.G.;Lorenzoni, E.;Stirpe, F.
  30. Arch. Pathol. v.70 no.1 Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog Jennings, R.B.;Sommers, H.M.;Smyth, G.A.;Flack, H.A.;Linn, H.
  31. Lipids v.11 Autoxidation of polyunsaturated fatty acids(II) Pryor, W.A.;Stanley, T.P.;Blair, E.
  32. Adv. Enzymol. v.32 Theroleofglutathione andglutathione S-tr-ansferaseinmercapturic acid biosynthesis Boyland, E.;Chasseud, L.F.
  33. Pharmacol. Ther. v.37 no.2 Glutathione, free radicals and chemotherapeutic agents : Mechanism of free radical induced toxicity and glutathione dependent protection Ross, D.