The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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A Study on the Effects of Honey-fried Astragali Radix Extract on the Nephrotoxicity in Rats Induced by Cyclosporin A

밀적황기(蜜炙黃耆)가 Cyclosporin A로 유발(誘發)된 백서(白鼠)의 신독성(腎毒性)에 미치는 영향(影響)

  • Park, Moo-Kyung (Dept. of Internal Medicine, College of Oriental Medicine Kyung Won University) ;
  • Park, Se-Ki (Dept. of Internal Medicine, College of Oriental Medicine Kyung Won University) ;
  • Kim, Dong-Woo (Dept. of Internal Medicine, College of Oriental Medicine Kyung Won University) ;
  • Han, Yang-Hee (Dept. of Internal Medicine, College of Oriental Medicine Kyung Won University) ;
  • Jun, Chan-Yong (Dept. of Internal Medicine, College of Oriental Medicine Kyung Won University) ;
  • Park, Chong-Hyeong (Dept. of Internal Medicine, College of Oriental Medicine Kyung Won University)
  • 박무경 (경원대학교 대학원 한의학과 내과학교실) ;
  • 박세기 (경원대학교 대학원 한의학과 내과학교실) ;
  • 김동우 (경원대학교 대학원 한의학과 내과학교실) ;
  • 한양희 (경원대학교 대학원 한의학과 내과학교실) ;
  • 전찬용 (경원대학교 대학원 한의학과 내과학교실) ;
  • 박종형 (경원대학교 대학원 한의학과 내과학교실)
  • Published : 1999.06.30
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Abstract

The purpose of this study is to find out the effects of honey-fried Astragali Radix extract on the nephrotoxicity in rats induced by cyclosporin A(CsA). The experimental rats were divided into three groups of ten. The Normal group was given nothing. The Control group was given only saline water every day for 14 days after the subcutaneous IV injection of 50mg/kg in CsA every other day during a period of 14 days. The sample group was administered 4.8mg/200g of Astragali Radix extract daily for 14 days after the subcutaneous IV injection of 50mg/kg in CsA every other day for 14 days. These groups were observed for 14 days. This experimental research focused on measuring the levels of BUN, creatinine, total protein, sodium, potassium, chloride, AST and ALT in the serum and specific gravity and creatinine in the urine. The results were summarized as follows: 1. Changes in serum The levels of BUN, creatinine. AST and ALT in the serum were significantly decreased in the sample group as compared with those of the control group. Total Protein level in the serum was significantly increased in the sample group as compared with that of the control group. Sodium and Potassium levels in the serum in the sample group were a little lower than those of the control group but no significance was noted. The chloride level in the serum in the sample group significantly increased as compared with that of the control group on the 7th day but in the sample group was significantly decreased as compared with that of the control group on the 14th day 2. Changes in urine Urinary specific gravity in the sample group showed significant increase, compared to the control group on the 7th day but were a little higher than that of the control group on the 14th day. Creatinine level in the urine were a little higher than that of the control group but no significance was found. These results suggest that honey-fried Astragali Radix might be effective on the nephrotoxicity in rats caused by CsA.

Keywords

References

  1. 臨宋藥理學 金學成;許근
  2. Closporin A가 體液性 및 細胞性 免疫反應에 미치는 影響 吳鐘鉉
  3. 臨床病理파일 (제2판) 이귀녕;이종순
  4. 이우주의 약리학강의(제3판) 홍사석
  5. 全國中草藥匯編 v.上冊 全國中草藥匯編 編寫組(編)