The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Effects of Complex formula including Korea Red Ginseng (CKRG) on Brain Ischemia Induced by Occlusion of Middle Cerebral Artery

고려홍삼 복합방이 실험적 뇌경색에 미치는 영향

  • 오상진 (충남대학교 생화학과) ;
  • 박일현 (충남대학교 생화학과) ;
  • 김성훈 (경희대학교 동서의학대학원)
  • Published : 1999.03.30
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Abstract

This study was performed to investigate the effect of complex formula(CKRG) consisting of Panax ginseng Radix rubra Koreana. Ganoderma, Cinnamomi Cortex, Glycyrrhizae Radix and Laminariae Thallus on brain ischemia and injury such as KCN-induced brain injury, forced brain ischemia, pulmonary thrombosis. The results were summarized as follows: 1. CKRG extracts showed a decrease of the duration of KCN-induced coma and showcd an increase in life expectancy. 2. CKRG extracts showed a decrease of neurologic grade in hind limb but did not affect neurologic grades in fore limb. Also. CKRG extracts showed a significant decrease of brain ischemic area and edema in MCA occlusion, 3. CKRG extracts showed a protective effect on pulmonary thrombosis induced by collagen and epinephrine. These data suggested that CKRG extracts could be applied to the protection of brain ischemia and injury.

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References

  1. 醫經溯회集 王安道
  2. 東醫心系內科學 v.上;下 全國韓醫科大學 心系內科學敎室(編)
  3. 成人病,老人病學 徐舜圭
  4. J. Pharmacol. Exp. Ther. v.162 no.2 Antagonism of wxperimental cyaride toxicity in relation to the in vivo activity of cytochrome oxidase. Schubert, J.;Brill, W.A.
  5. Stroke v.20 Correlation of between cerbral blood flow and histologic changes in a new rat model of cerebral artery occlusion. Nagssawa, H.;Kogure, K.
  6. Stroke v.17 Rat middle cerebral artery occlusion : Evaluation of the model and development of a neurologic examination. Bendrson, J.B.;Potts, L.H.;Tsuji, M.;Nishimura, M.C.;Davis, R.L.;Bartkowski, H.
  7. Arzneim. Forsh. Drug Res. v.35 no.II Effect of cilostazol on platelet aggregation and experimental thrombosis. Kimura, Y.;Tani, T.;Watanabe, K.
  8. 病理學 大韓病理學會(編)
  9. Arch Neurol v.29 The clinical problem how much anoxia-ischemia damages the brain? Plum, F.
  10. WILEY MEDICAL PUBLICATION Textbook of Biochemistry with clinical correlations. Devlin, Thomas M.
  11. 최신고려인삼 한국인삼연초연구원
  12. 方藥合編 黃度淵
  13. 경희의학 v.7 no.3 최근 뇌졸중에 대한 역학적 고찰 나영설(외)
  14. 뇌졸중에 관한 임상통계적 연구 v.19 윤진구
  15. Robbins pathologic basis of disease Robbins, Cotran. K.
  16. 국립보건안전연구원보 v.7 no.1 뇌허혈 동물모델을 이용한 뇌기능 개선제의 효능에 관한 연구(1) 정혜주(외)
  17. Circulation v.60 Simplified method fro histochemical demonstration of experimental myocardial infarct Fallon, J.T.
  18. 대한신경외과과학회지 v.1 no.1 뇌부종의 정의와 기전 정환영