The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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Neuropathic Pain Management with NMDA Receptor Antagonist (Ketamine) in Pain Clinic -A case report-

NMDA 수용체의 길항제인 Ketamine를 이용한 신경병증성 통증 치료

  • Ahn, Mi-Jung (Department of Anesthesiology, Chungnam National University College of Medicine) ;
  • Kim, Hae-Ja (Department of Anesthesiology, Chungnam National University College of Medicine) ;
  • Lee, Won-Hyung (Department of Anesthesiology, Chungnam National University College of Medicine) ;
  • Shin, Yong-Sup (Department of Anesthesiology, Chungnam National University College of Medicine) ;
  • Lee, Jung-Un (Department of Anesthesiology, Chungnam National University College of Medicine)
  • 안미정 (충남대학교 의과대학 마취과학교실) ;
  • 김혜자 (충남대학교 의과대학 마취과학교실) ;
  • 이원형 (충남대학교 의과대학 마취과학교실) ;
  • 신용섭 (충남대학교 의과대학 마취과학교실) ;
  • 이정은 (충남대학교 의과대학 마취과학교실)
  • Published : 1998.10.10
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Abstract

The feature of neuropathic pain may occur in the absence of any apparent stimulus and be exaggerated in either amplitude or duration. Peripheral nerve injury may produce neuropathic pain and opioids have been shown to be relatively unsatisfactory for the treatment of most cases of neuropathic pain. The NMDA receptor system is involved in transmission and modulation of nociceptive information. We treated patients with severe pain, hyperaesthesia and allodynia with epidural injection of NMDA receptor antagonist, ketamine (10 mg) and morphine (0.5 mg) or other opioid. The combinations provided effective pain management in 23 patients with neuropathic pain.

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