Analytical Science and Technology (분석과학)
- Volume 11 Issue 3
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- Pages.161-166
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- 1998
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- 1225-0163(pISSN)
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- 2288-8985(eISSN)
Determination of Haloperidol Serum Levels in Psychiatric Patients with Gas Chromatography-Nitrogen Phosphorus Detection
GC/NPD를 이용한 정신분열증 환자의 혈중 Haloperidol 정량분석
- Paik, Man-Jeong (Seoul Clinical Laboratories(SCL), Seoul Medical Science Institute) ;
- Kang, Bo-Kyoung (Seoul Clinical Laboratories(SCL), Seoul Medical Science Institute) ;
- Lee, Kyoung-Ok (Seoul Clinical Laboratories(SCL), Seoul Medical Science Institute) ;
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Shin, Ho-Sang
(Department of Environmental Education, Kongju University)
- 백만정 (서울임상병리검사센터(SCL).서울과학연구소) ;
- 강보경 (서울임상병리검사센터(SCL).서울과학연구소) ;
- 이경옥 (서울임상병리검사센터(SCL).서울과학연구소) ;
-
신호상
(공주대학교 환경교육학과)
- Received : 1997.10.24
- Published : 1998.06.01
Abstract
Analytical method of haloperidol (HAL) in serum which has been widely used in therapy of schizophrenic disorders is developed. Gas chromatography/nitrogen-phosphorus detection (GC/NPD) was used for this study. Bromoperidol was used as an internal standard and diethylether as a solvent of three-step extraction. The extraction yield in this procedure was
정신질환 치료에 가장 폭넓게 사용되는 haloperidol(HAL)의 혈중농도 분석법이 개발되었다. 이 연구를 위하여 gas chromatography/nitrogen-phosphorus detection(GC/NPD)을 이용하였으며, bromoperidol을 내부표준물질로 사용하였고, 시료전처리 방법으로써 diethylether를 추출용매로 사용하는 3단계 추출법을 사용하였다. 이 과정에 있어서 추출효율은 15 ng/mL에서