A Study on the Morphogenesis of Human Fetal Hepatic Tissue

사람태아 간조직의 형태형성에 관한 연구

  • Deung, Young-Kun (Department of Basic Science and Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University) ;
  • Kim, Dong-Heui (Department of Basic Science and Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University)
  • 등영건 (연세대학교 원주의과대학 기초의학교실) ;
  • 김동희 (연세대학교 원주의과대학 기초의학교실)
  • Published : 1998.09.01

Abstract

Hemopoiesis and morphogenesis of the human fetal liver through from 10 to 32 weeks of gestation were investigated by light and electron microscopy. The results obtained were as follows. Hemopoiesis of fetal liver tissue was found from 10 to 32 weeks of gestation, but the hemopoiesis was decreased at 32 weeks of gestation. At the 32 weeks of gestation, matured erythrocytes were observed in the sinusoid, and formation of liver cell cord and portal triad were established. Differentiation of hepatic cell was characterized by the increase of amount of cell organelles within cytoplasm, decrease of hemopoietic cell, morphological change of nuclear envelope from folding form to round form during the developmental period. These results suggest that human fetal liver plays a hematopoietic function until bone marrow and spleen play their function, but morphology of liver at 32 weeks of gestation was differed with structure observed in liver of adult.

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