Archives of Pharmacal Research
- Volume 21 Issue 6
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- Pages.657-663
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
NO/cGMP Pathway is Involved in Exocrine Secretion from Rat Pancreatic Acinar Cells
- Ahn, Seong-Hoon (College of Pharmacy, Sungkyunkwan University) ;
- Seo, Dong-Wan (College of Pharmacy, Sungkyunkwan University) ;
- Ko, Young-Kwon (College of Pharmacy, Sungkyunkwan University) ;
- Sung, Kae-Suk (College of Pharmacy, Sungkyunkwan University) ;
- Bae, Gyu-Un (College of Pharmacy, Sungkyunkwan University) ;
- Yoon, Jong-Woo (College of Pharmacy, Sungkyunkwan University) ;
- Hong, Sung-Youl (College of Life Science and Natural Resources, Sungkyunkwan University) ;
- Han, Jeung-Whan (College of Pharmacy, Sungkyunkwan University) ;
- Lee, Hyang-Woo (College of Pharmacy, Sungkyunkwan University)
- Published : 1998.12.01
Abstract
The enzyme responsible for the synthesis of nitric oxide (NO) from L-arginine in mammalian tissues is known as nitric oxide synthase (NOS) (EC.1.14.13.39). In the present study, the role of NO in the regulation of exocrine secretion was investigated in rat pancreatic acinar cells. Treatment of rat pancreatic acinar cells with cholecystokinin-octapeptide (CCK-OP) resulted in an increase in the arginine conversion to citrulline, the amount of