The Journal of Korean Society of Virology (대한바이러스학회지)

The Korean Society of Virology (대한바이러스학회)
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Detection of Antibodies against Shope Fibroma Virus and Formation of Fibroma in the Korean Domestic Rabbits

한국산 가토에서의 Shope Fibroma Virus에 대한 항체증명과 섬유종 형성에 관한 연구

  • Yang, Hyun-Ok (Department of Traditional Medicine, Asan Institute for Life Sciences) ;
  • Park, Kun-Koo (Department of Traditional Medicine, Asan Institute for Life Sciences) ;
  • Ryu, Sun-Ja (Department of Virology, Asan Institute for Life Sciences) ;
  • Woo, Young-Dae (Department of Virology, Asan Institute for Life Sciences) ;
  • Joo, Yong-Kyu (Department of Virology, Asan Institute for Life Sciences) ;
  • Lee, Ho-Wang (Department of Virology, Asan Institute for Life Sciences)
  • 양현옥 (아산생명과학연구소, 전통의학연구실) ;
  • 박건우 (아산생명과학연구소, 전통의학연구실) ;
  • 류선자 (아산생명과학연구소, 바이러스연구실) ;
  • 우영대 (아산생명과학연구소, 바이러스연구실) ;
  • 주용규 (아산생명과학연구소, 바이러스연구실) ;
  • 이호왕 (아산생명과학연구소, 바이러스연구실)
  • Published : 1998.12.30
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Abstract

In our preliminary study to find antiviral or antitumor agents from Korean natural products, we found that the Shope fibroma virus (SFV) induced fibromas reaching maximum size at $5{\sim}6$ days with spontaneous disappearance at $15{\sim}20$ days after SFV intracutaneous inoculation into Korean domestic rabbits. However, the sizes of fibromas of rabbits at day 5 after virus inoculation were significantly different individually. Assuming that the variation of tumor size was due to either susceptibility or the preexisting antibodies against SFV in the Korean domestic rabbits, the rabbits were checked for the antibodies against SFV by IFAT using SFV infected RK13 cells. The antibody positive rate of normal Korean domestic rabbits was 32.8% and the sizes of the fibromas of the positive rabbits were significantly smaller than those of negative rabbits (p<0.0001). The fibroma sizes were dependent on the antibody titers of rabbits to SFV. The sizes of fibromas after inoculation of SFV into immunized rabbits were about one tenth of those by the first inoculation into normal rabbits. This is the first report on the antibody prevalence against SFV among normal Korean domestic rabbits and it suggest the existence of a wild fibroma virus or related virus in Korea.

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