Anticonvulsant Effect of Uncariae Ramulus et Uncus III. - Effects of Ursolic Acid and Hyperin on Neurotransmitters related Components in Brain Tissue In Vitro -

조구등(釣鉤藤) 성분의 항경련효과 III. - Ursolic Acid와 Hyperin이 In Vitro 뇌 신경전달 관련물질에 미치는 효과 -

The ethyl acetate fraction of Uncariae Ramulus et Uncus, which showed anticonvulsant effects against pentylenetetrazole (PTZ) treated mice, were subjected to column chromatography to isolate ursolic acid and hyperin from active eluate. Hyperin decreased the elevated activities of GABA-T and xanthine oxidase and lipid peroxide level dose-dependently in PTZ treated mice brain tissue in vitro, but no effect on superoxide dismutase activity. The effects on such enzyme and component seemed to be related with biosynthesis or metabolism of neurotransmitters.