Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Protective Effects of Silymarin and Biphenyl Dimethylene Dicarboxylate and Their Combined Doses on Hepatotoxicity of Rats Induced by Carbon Tetrachloride

사염화탄소로 유발한 흰쥐의 간독성에 대한 Silymarin과 Biphenyl Dimethylene Dicarboxylate 및 그 혼합 투여시의 억제 효과

  • Kim, Ock-Kyung (College of Science and Technology, Daegin University) ;
  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University)
  • Published : 1998.06.30
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Abstract

The increased AST and ALT activities of rat serum disturbed by $CCl_4-intoxication$ intoxication were significantly inhibited by silymarin and biphenyl dimethylene dicarboxylate at the oral doses of 150 and 5 mg/kg, respectively. The combined administration of the drugs showed remarkable inhibition of the enzyme activities. This fact may suggest that the two drugs have potentiative action in this experiment.

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