YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Bilobalide Attenuates Glutamate-Induced Neurotoxicity in Primary Cultures of Rat Cortical Cells

빌로바라이드가 글루타메이트에 의한 신경독성에 미치는 영향

  • Published : 1997.02.01
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Abstract

The neurotoxicity induced by L-glutamate in primary cultures of rat cortical cells could be attenuated by sesquiterpene constituent of Ginkgo biloba leaves, bilobalide. At the c oncentration of 100 nM, Bilobalide elevated the combined levels of reduced/oxidized glutathione in rat cortical cells exposed to 100 ${\mu}$M glutamate. Furthermore, bilobalide promoted a reduction in superoxide dismutase activity in glutamate-treated cells. Finally, bilobalide markedly inhibited the production of malondialdehyde. a measure of lipid peroxidation, in glutamate-treated rat cortical cells.

Keywords

References

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