Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Production of Elaiophylin by the Strain MCY-846 in a Submerged Culture

  • Lee, Sang-Yong (Department of Microbiology, Kyungpook National University) ;
  • Ha, Sang-Chul (Natural Products Biosynthesis R.U., Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Hong, Young-Soo (Natural Products Biosynthesis R.U., Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Hong, Soon-Duck (Department of Microbiology, Kyungpook National University) ;
  • Lee, Jung-Joon (Natural Products Biosynthesis R.U., Korea Research Institute of Bioscience and Biotechnology (KRIBB))
  • Published : 1997.08.01
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Abstract

Streptomyces sp. MCY-846 selected by in vitro cytotoxicity assay produced elaiophylin. Individual characteristics of the strains such as spore morphology, and physiological characteristics indicated that the strain is resembled to Streptomyces hygroscopicus. The time course of cell growth and antibiotic production was observed in the medium containing 0.5% trehalose and 0.5% soybean meal as carbon and nitrogen sources, respectively. The optimum production of elaiophylin was tested with different combinations of carbon and nitrogen sources and reached a maxima of $470{\mu}$/ml in the PC-II medium.

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