식이지방의 종류와 Guar Gum의 첨가가 난소절제한 흰쥐의 지질대사에 미치는 영향

Effect of Dietary Lipids and Guar Gum on Lipid Metabolism in Ovariectomized Rats

  • 안혜선 (한양대학교 식품영양학과)
  • 발행 : 1997.12.01

초록

This study examined the effect of dietary lipids and guar gum on lipid metabolism in ovariectomized rats. The experimental animals received ovarietomy (OVX). Lipids sources were divided into 3 groups (soybean oil(SB), beef tallow(BT)) and fish oil(FO)) and guar gum was supplemented to each lipid diet (SBG, BTG, FOG). Experimental diets were fed to therats for 16 weeks. Serum triglyceride (TG) levels were higher in the BT group and lower in the FO group as compared to the SB group .Serum total cholesterol (Tc) and HDL-C levels were lower in the FO group as compared to the SB group. Serum LDL-C and phospholipid levels were lower in the FO group as compared to the SB group. Serum lipids levels were lowered by guar gum supplement. Serum SFA(saturated fatty acids) contents were not significantly influenced by dietary lipids and guar gum. Serum MUFA(monounsaturated fatty acids) contents were the lowest in the SB group. Fecal weight was highest in the beef tallow group and lowest in the fish oil group. Fecal weight was increased by guar gum supplement in all lipid groups. Total bile acid content in feces was increased by guar gum supplement in the soybean oil and beef tallow groups. The endothelial cells of the beef tallow group changed from a flat shape to distorted round and enlarged shapes. The subendothelial layer was the thickness the thickest in the beef tallow group ; the interspace between elastic lamina was widened and elastic lamina was straightened and partly disrupted . The fish oil group showed more porminient endothelial cells and subendothelial layer. Internal elastic membrane and elastic lamina exhibited regularly wavy shapes. Guar gum supplement showed positive effects in all lipids groups. Based on the above results , it is suggested that beef tallow increased serum TG levels and injured the wall of the aorta. On the other hand, fish oil , which decreased serum lipid levels, has a positive effect on the walls of the aorta. Guar gum protects the aorta from injury by reducing the serum lipid levels. Therefore, it is suggested that soybean oil and beef tallow consumed with guar gum is beneficial.

키워드

참고문헌

  1. Am J Obstes Gynecol v.160 Cardiovascular benefits of estrogen replacement therapy Ross,R.K.;Paganini-Hill,A.;Mack,T.M.;Henderson,B.E.
  2. Metabolism v.39 no.10 Differences in apolipoproteins and low density lipoprotein subfractions in postmenopausal women on and off estrogen therapy : Results from the Framingham offspring study Campos,H.;Wilson Peter W.F.;Jimenez,D.;Mcnamara,J.R.;Ordovas,J.;Schaefer,E.J.
  3. New Engl J Med v.325 no.17 Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins Walsh,B.W.;Schiff,I.;Rosner,B.;Greenberg,L.;Ravnikar,V.;Sacks,F.M.
  4. Am J Obstet Gynecol v.163 no.1 Role of plasma lipoproteins in the pathogenesis of atherosclerotic disease, with special reference to sex hormone effects Tikkanen,M.J.
  5. 대한영양사회 학술세미나 바람직한 지방산의 섭취 이양자
  6. Br J Nutr v.47 Effect of moderate increase in dietary polyunsaturated : saturated fat on plasma triglyceride and cholesterol levels in man Kramer,F.B;Greenfield,M.
  7. Am J Clin Nutr v.31 The effect of a fish diet on serum lipids in healthy human subjects Von Lossonczy T.O.;Ruiter,A.;Bronsgeest-Schoute H.C.;Van Gent C.M.;Hermus,R.J.J.
  8. Am J Clin Nutr v.39 Effects of grar gum in male subjects with hypercholesterolemia Aro,A.;Uusitupa,M.;Voutilainen,E.;Korhonen,T.
  9. Plant Foods Hum Nutr v.41 Hypocholesterolemic effect of guar gum in overweight adults Kawatra,A.;Kapoor,A.C.;Seghal,S.
  10. 한국영양학회지 v.30 no.3 서울지역 일부 중학생의 성장발육 및 영양실태 하명주;계승희;이행신;서성제;강윤주;김초일
  11. 한국영양학회지 v.30 no.3 내인성 및 외인성 Estrogen이 관상심장질환 위험 인자에 미치는 영향 박유신;권종숙;장유경
  12. Korean J Nutrition v.30 no.4 Effects of dietary fatty acids on serum lipids and fatty acid composition of serum phospholipids in men Oh,E.J.;Kwon,J.S.;Chang,Y.K.
  13. 한국영양학회지 v.30 no.3 쑥 및 엉겅퀴가 식이성 고지혈증 흰쥐의 심혈관계에 미치는 영향 임상선;이종호
  14. Clin Chem v.18 Estimation of low density lipoprotein cholesterol in plasma, without use of the preparative ultra-centrifuge Fredelwald,W.T;Levy,R.I;Fedreiczon,D.S.
  15. Poul Sci v.63 A comparison of various procedures for determining total yolk lipid content Fletcher,D.L.;Britton,W.M.;Cason,J.A.
  16. J Lipid Res v.27 Lepage,G.;Roy,C.C. Direct transesterification of all classes of lipids in a one-step reaction
  17. J Lipid Res v.6 Quantitative isolation and gas-liquid chromatographic analysis of total dietary and fecal neutral steroids Miettinen,T.A.;Ahrens,E.H.;Grundy,S.M.
  18. Basic histology(Sixth edition) Junqueira,L.C.;Carneiro,J.;Kelly,R.O.
  19. Am J Clin Nutr v.38 The hypolipidemic effect of locust bean gum food products in familial hypercholesterolemic adults and children Zavoral,J.H.;Hannan,P.;Fields,D.J.
  20. J Clin Endocrinol Metab v.66 Effects of endogenous sex steroids on serum lipoproteins and postheparin plasma lipolytic enzymes Sorva,R.;Kuusi,T.;Dunkel,L.;Takinen,M.R.
  21. Am J Clin Nutr v.54 High-fiber diet reduces serum estrogen concentrations in premenopausal women Rose,D.P.;Goldman,M.;Connolly,J.M;Strong,L.E.
  22. Acta Med Scand v.192 Fatty acid composition of serum lipids in man with myocardial infarction Kirkeby,K.;Ingvaldsen,P.;Bierkedal,I.
  23. Cancer v.28 Epidemiology of cancer of the colon and rectum Burkitt,D.P.
  24. 한국영양학회지 v.29 no.1 식이섬유소 섭취상태와 변 담즙산 조성과의 관계 황은희
  25. Am J Clin Nutr v.53 Serum lipid and fecal bile acid changes with cereal. vegetable, and sugar-beet fiber feeding Lampe,J.W.;Slavin,J.L.;Baglien,K.S.
  26. Inter Soc Immuno The effect of a high-fat diet on murine macrophage activity Strwart-Phillips,J.L;Lough,J.;Phillips,N.C.
  27. N Engl J Med v.318 no.9 Cardiovascular effects of n-3 fatty acids Leaf,A.;Weber,P.C.
  28. Science v.22 Fish oils inhibit endothelial cell production of platelet-derived growth factor like protein Dicorleto,P.E.;Fox,P.L.
  29. Bone Miner v.11 The ovariectomized, lactating rat as an experimental model for osteopenia : calcium metabolism and bone changes Anderson,J.J.B.;Garner,S.C.;Mar,M.H.;Boass,A.;Toverud,S.U.;Parikh,I.