Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Antigenicity of EPO (Erythropoietin) in Guinea Pigs, Mice and Rats

기니픽, 마우스 그리고 랫드에서 EPO (Erythropoietin)의 항원성에 관한 고찰

  • 이학모 (서울대학교 수의과대학 공중보건학교실) ;
  • 남정석 (서울대학교 수의과대학 공중보건학교실) ;
  • 제정환 (서울대학교 수의과대학 공중보건학교실) ;
  • 이석만 (서울대학교 수의과대학 공중보건학교실) ;
  • 양재만 (서울대학교 수의과대학 공중보건학교실) ;
  • 강병철 (서울대학교 수의과대학 공중보건학교실) ;
  • 박재학 (서울대학교 수의과대학 실험동물의학교실) ;
  • 송동호 ((주)녹십자) ;
  • 유선희 ((주)녹십자)
  • Published : 1997.06.01
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Abstract

The antigenicity of EPO (erythropoietin) was investigated in guinea pig, mice and rats. Antigenicity tests-active systemic anaphylaxis (ASA), passive cutaneous anaphylaxis (PCA) of this materials were performed according to the established Regulation of Korean National Institute of Safety Research (1996, 4, 16). The results were followed: 1. After sensitizaion with EPO emulsified with complete Freund's adjuvant (CFA), guinea pigs didn't show any anaphylatic shock symptom in the ASA test 2. After sensitization with antisera of EPO sensitized mice, blue spots were observed on the hypodermis of back of rats in the PCA test, but diameter of each spot was smaller than 5 mm. From the results of this investigation, the antigenicity of EPO was negative under the present experimental condition.

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References

  1. Am. J. Hematol. v.42 An unusual and unpredicted toxicity to erythropoietin Buchbinder A.;Adler H.;Ballard H.
  2. Erythropoietin Production in hypoxemic rats with selective necrotic damage of the different resions of the proximal tubules Giglio M.J.;Frid A.;Arrizurrieta E.;Barcat J.;Gonzalez E.;Bozzini C.E.
  3. Progress in drug research v.41 Recent advances in erythropoietin research James W;Fisher J.W.;Ernst Jucker(eds.)
  4. 藥理と治療 v.18 Metabolic fate of erythropoietin (TYB-5220) Kazuo O.;Shoichi A.;Takako S.;Tomako O.;Naoki N.;Yoshiko I.
  5. Mutagenesis v.8 no.3 Induction of micronucleated erythrocytes by recombinant human erythropoietin Yajima N.;Kurata Y.;Sawai T.;Takeshita Y.