Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Four-Week Intravenous Toxicity of EPO(Erythropoietin) in Rats

랫드에서 EPO(erythropoietin)의 4주간 정맥 반복투여 독성시험

  • 남정석 (서울대학교 수의과대학 공중보건학실) ;
  • 제정환 (서울대학교 수의과대학 공중보건학실) ;
  • 이석만 (서울대학교 수의과대학 공중보건학실) ;
  • 양재만 (서울대학교 수의과대학 공중보건학실) ;
  • 강병철 (서울대학교 수의과대학 공중보건학실) ;
  • 이학모 (서울대학교 수의과대학 공중보건학실) ;
  • 박재학 (서울대학교 수의과대학 실험동물의학교실) ;
  • 송동호 ((주)녹십자) ;
  • 유선희 ((주)녹십자)
  • Published : 1997.06.01
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Abstract

Group of 40 male and 40 female Sprague-Dawley rats were given daily intravenous injections of different dosage of Erythropoietin (EPO), 80 IU/ kg/day (low dosage group), 400 IU/ kg/day (middle dosage group), or 2000 IU /kg/day (high dosage group)for 4 weeks by tail vein according to Established Regulation of Korean National Institute of Safety Research (1994. 4. 14). Appearance, behavior, mortality, and food consumption of rats of treated groups were not affected during the experimental periods. No significant EPO (erythropoietin)-related changes were found in urinalysts, eye examination, hematology, serum chemistry, and organ weight. No histopathological lesions were observed in both control and treatment groups. Our results strongly suggest that no toxic changes were found in rat treated intravenously with EPO (erythropoietin)for 4 weeks.

Keywords

References

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