Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Suppressive Effects of Triterpenoids on CINC-1 Induction in Interleukin-1{\betha}-stimulated rat fibroblast NRK-49F cells

  • Ha, Joo-Young (College of Pharmacy, Chungbuk National University) ;
  • Min, Kyung-Rak (College of Pharmacy, Chungbuk National University) ;
  • Kang, She-Hoon (College of Pharmacy, Chungbuk National University) ;
  • Kim, Ju-Sun (Natural Products Research Institute, Seoul National University) ;
  • Lee, Gyeong-Im (College of Pharmacy, Chungbuk National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University) ;
  • Kim, Youngsoo (College of Pharmacy, Chungbuk National University)
  • Published : 1997.06.01
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Abstract

CINC-1 is a member of chemokine family with chemotactic and activating properties to neutrophils. CINC-1 induction in IL-$1{\beta}$-stimulated rat fibroblast NRK-49F cells was quantitated by a sensitive ELISA. CINC-1 production was increased up to 135 ng/ml from basal 2-6 ng/ml by stimulation with IL-$1{\beta}$.Steroidal anti-inflammatory drugs including dexamethasone and prednisolone exhibited potent suppressive effects on IL-$1{\beta}$-induced CINC-1 production. Among 39 kinds of natural triterpenoids tested, acacigenin B exhibited the highest suppressive effects with about $10{\mu}M$ to be 50% of inhibition on the CINC-1 induction. The suppressive potency of acacigenin B on IL-$1{\beta}$induced CINC-1 production was about 10-fold less than that of the steroidal anti-inflammatory drugs.

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