Effects of Several Herbs on the Immune Responses

수종 한약재가 면역 반응에 미치는 영향

  • Song, Bong-Keun (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
  • 송봉근 (원광대학교 한의과대학 내과학교실)
  • Published : 1997.10.30

Abstract

It was claimed that the herbal medicine with the function of strengthening the body resistance exerts to enhance the immunity. And the medicine with the effect of eliminating the pathogenic factor is stated to inhibit the immune response. To evaluate the the effects of the herbal medicine on the immune response, the mice were administrated with the herbal medicine for 2 weeks. And the responses were analyzed. As the result, water extract of Radix Astragali, Fructus Psoraleae, Cortex Acanthopanacis, Semen Coicis, Herba Ecliptae, Spica Prunellae, and Radix Sophorae increased the ROI production, while Radix Tripterygia inhibited it. Phagocytic activity was increased after administration of Radix Astragal, Fructus Psoraleae, Cortex Acanthopanacis, Herba Ecliptae, Spica Prunellae and Radix Sophorae. NK cell activity was also significantly inhibited by Radix Tripterygia. Administration of Radix Astragali, Fructus Psoraleae, Cortex Acanthopanacis, Herba Ecliptae, Spica Prunellae and Semen Coicis enhanced the antibodies(hemagglutinin and hemolysin) formation and the appearance of rosette forming cells of the spleen, while Radix Sophorae and Radix Tripterygia decreased it. Radix Sophorae and Radix Tripterygia also decreased the allogenic immune response and mixed-lymphocyte reaction. And all the experimental herbs decreased contact hypersensitivity against dinitroflurobenzene. These results show Radix Astragali, Fructus Psoraleae, Spica Prunellae, Cortex Acanthopanacis, Semen Coicis and Herba Ecliptae enhanced innate immunity, humoral and cellular immune responses. However Radix Sophorae and Radix Tripterygia exert imunosuppressive action. Also these results indicate that the medicine with the action of the strengthening the body resistance enhances the immunity. And the the some of drugs belonging to the eliminating the pathogenic factor also increase the immune responses.

Keywords

References

  1. 최신면역학 이연대
  2. 면역학입문 정헌택
  3. 한방병리학, 총론 정우열
  4. 中藥免疫藥理學 周金黃
  5. 中藥學 甘肅省新醫藥學硏究所
  6. Immunology v.14 A kinetic study of antibody producing cells in the spleen of mice immunized intravenously with sheep erythrocutes Biozzi G;Stiffel C;Mounton D;Bouthiller Y;Decrusefound C
  7. J. Nat. Cancer Inst. v.51 Immunopotentiation with BCGII, modulaton of the response to sheep red blood cells Miller TE(et al)
  8. Immunoiogy v.34 Delayed hypersensitivity in mice induced by intravenous sensit zation with sheep erythrocytes : evidence for tuberuclin type delayed hypersensitivity of the reaction Mitsuoka A(et al)
  9. Cell. Immunol. v.79 Persistent expression of IgA-antigen on a subpopulation of murine resident peritoneal macrophages. Walker WS;Hester RB;Beelen RHJ
  10. J. Vet. Med. v.834 Measuring phagocytic capacity in polymorphonu clear cell of the pig a comparison between different assay Winter M;Buschmann HG.
  11. Nature v.268 Dissociation of effector functions in populations of activated macrophages Winy EJ;Gardner ID;Ryminy FW;Reminyton JS
  12. Trans plantation v.5 The failure if thymusderived cells to produce antibody Davis AJS(et al)
  13. Eur J Immunol F4/80 monolonal antibody directed specifically against the mouse macrophage Austyn JM;Gordon S
  14. Anant Reac v.210 The monoeuclear phagocyte system of the mouse defines by immunohistochemical antigen F4/80 Hume DA;Perry VH;Gordon S
  15. Immunology, Immunopathology and immunity Sells S
  16. Cellular Immunology v.3 Antigen recognition by T lymphocytes Bach JF;Dardenne M
  17. Reticuloendothel. Soc. v.23 Macrophage growth factor and it's relationship to colony stimulation factor Stewart CC;Lin H
  18. Jpn. Kokai Tokkyo Koho v.81 G. L. antihypertensive component. Kubo M;Archi S
  19. J. Immunlo. Meth. v.86 A fluorescence NK assay using flow cytometry. McGrinnes KM;Chopman G;Marks R;Penny R.
  20. Immunopharmacol v.15 Functional and numerical alterations induced by ethanol in the cellular immune system. Mufti SI;Prahhala R;Moriguchi, Sipes IG;Watson RR.
  21. Soc. Exp. Biol. Med. Proc. v.59 Thymusmarrow cell combination synergism in antibody production Claman HN;Chaperon EA;Triplrtt RF
  22. Antigen-antibody interactions in basic exercises in immunochemistry Nowothy A
  23. Nature v.202 A simple method of detection single antibody forming cells Zaalberg OB
  24. Antibody formation at the cellular level in immunology Avrames L;Bach JF;Preud homme JL
  25. Cellular Immunology v.3 Antigen recognition by T lymphocytes Bach JF;Dardenne M
  26. J. Antibiot. v.38 Suppression of tissue graft rejection by spergualin. Umezawa H;M Ishizuka T;Takeuchi F;Abe K;Nemoto K
  27. Transplantation v.44 Effect of a new immunosuppressant, 15-deoxyspergualin, on heterotopic rat heart transplantation, in comparison with cyclos porine. Suzuki S;M Kanashiro;H Amemiya
  28. Cell Immunol v.101 Modification of the murine immune system be glucocorticoseroids of circulation lymp hocytes. Chung HT;Samlowski WE;Daynes RA
  29. Cell Immunol v.109 Ferritin selectively suppresses delayed-type hypersensitivity responses at induction or effector phase Kakayuki H(et al)
  30. J Immunol v.127 The effects of ultraviolet irradiation on the generation of anti tumor cytotoxic effector cell responses in vitro Lynch DH;Daynes RA
  31. J Antibiot v.41 Biological activities of deoxysper gualin in autoimmune disease mice Nemoto K;M Hayashi;Y Sugawara;J Ito;F Abe
  32. 면역학 서울대학교의과대학
  33. 上海中醫藥雜誌 v.6 虛證和實證病因的免疫狀態 章育正
  34. 中醫免疫學 戴新民
  35. 대한한의학회지 v.11 no.2 면역질환의 한방개념과 치료에 관한 문헌적 고찰 채우석
  36. 免疫と漢方 落和生
  37. 中藥藥理與應用 王浴生
  38. Clin Invest v.52 Biological defence mechanism ; The production by leulocyte of superxoide, a potential bactericidal agent Babior BM;Kipnes RS;cumutte JT
  39. Int J Tiss Reac v.11 no.1 An experimental model for hydrogen peroxide induced tissue damage : Effect on cartilage and other articular tissues Schalwijk J;Vanderberg WB;Vandeputte LBA;Loosten LBA
  40. J Immunol v.127 Nature killer cells in the mouse Kiessling R
  41. Nature v.202 A simple method for detection single antibody forming cells Zaalberg OB