Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
권호 표지

Experimental studies on anti-tumor and immunomodulatory effects according to it's

종양(腫瘍)의 치법(治法)에 관(關)한 실험적(實驗的) 연구(硏究) -부정법(扶正法), 부정거사법(扶正祛邪法), 공사법(攻邪法)의 비교연구(比較硏究)-

  • Kim, Sun-Hee (DEPARTMENT OF ORIENTAL MEDICINE OF KYUNGSAN UNIVERSITY) ;
  • Choi, Jong-Baek (DEPARTMENT OF ORIENTAL MEDICINE OF KYUNGSAN UNIVERSITY) ;
  • Kim, Sang-Chan (DEPARTMENT OF ORIENTAL MEDICINE OF KYUNGSAN UNIVERSITY)
  • 김선희 (경산대학교 한의과대학 본초방제학교실) ;
  • 최종백 (경산대학교 한의과대학 폐계내과) ;
  • 김상찬 (경산대학교 한의과대학 본초방제학교실)
  • Published : 1997.12.20
Download PDF
⟨ Previous Next ⟩

Abstract

This study was aimed to investigate the anti-tumor and immune response effect of Samyongtang(S1; this medicine represents for 'ENERGIZER'), Yangjeongjejeoktang(S2; this is the 'INTERMEDIATE METHOD' of S1 and S3) and Onbeakwon(S3; this is 'ATTACK' the disease of mass) on the experimental rats induced by Sarcoma-180 and Methotrexate. And to observed the differences S1, S2, and S3 treatment groups. Tumor weight(TW) in vivo, interleukin-2(IL-2), hemagglutinin titer(H.A), hemolysin titer(HL), rossete forming cell(RFC), delayed type hypersensitivity(DTH), and natural killer cell activity(NKCA) in vivo were measured in rats. The obtained results were summarized as follows. 1. Tumor weight was decreased in all treatment groups (S2>S3>S1) as compared with control group, but the difference was not statistically significant each treatment groups. 2. Interleukin-2 was increased in all treatment groups (S1>S2>Ss) as compared with control group, but the difference was not statistically significant each treatment groups. 3. Hemagglutinin titer was increased in all treatment groups (S1>S2>S3) as compared with control group, but the difference was not statistically significant each treatment groups. 4. Hemolysin titer was increased in all treatment groups (S1>S2>S3) as compared with control group, but the difference was not statistically significant each treatment groups. 5. Rossete forming cell(RFC) was increased in all treatment groups (S1>S2>S3) as compared with control group, but the difference was not statistically significant each treatment groups. 6. Delayed type hyperseneitivity(DTH) was increased in S1, S2 treatment groups (S1>S2) as compared with control group, but it was decreased in S3 treatment group. Therefore, S1 group was statistically significant compared with S3 groups. 7. Natural killer cell activity(NKCA) was increased in all treatment groups (S2>S3>S1) as compared with control group, but the difference was not statistically significant each treatment groups. Based on the above mentioned results, it is suggested that S1, S2 and S3 will have anti-tumor substances and enhance effect of immune response. But the differences were not statistically significant in each treatment groups, except for delayed type hypersensitivity.

Keywords

References

  1. 病理學 金春元
  2. 성인병$\cdot$노인의학 徐舜圭
  3. 廣濟秘급 李景華
  4. 大韓韓醫學會誌 v.12 no.2 加減生肝湯을 投與한 肝癌患者에 關한 硏究 金東佑;金德鎬(외)
  5. 大韓免疫學會誌 v.5 no.1 癌患者에서의 T, K, NK세포 및 단구의 기능 저하 김재광(외)
  6. 大韓韓方腫瘍學會誌 v.1 no.1 비氣丸이 抗腫瘍 免疫反應에 미치는 影響 文炳河(외)
  7. 大韓韓方腫瘍學會誌 v.1 no.1 징가에 사용되는 歸朮破징湯과 加味歸朮破징湯의 效能에 關한 硏究 宋錫鎬(외)
  8. 慶熙大學校大學院 博士學位論文 白鼠를 利用한 枳實 魚腥草 穿山甲 및 저령의 抗癌效果에 關한 硏究 沈載然
  9. 慶熙大學校大學院 碩士學位論文 靈芝, 山慈고, 仙鶴草, 卷柏, 瓦松이 흰쥐의 自然殺害細胞活性에 미치는 影響 梁緖賢
  10. 慶熙大學校大學院 博士學位論文 易黃湯이 利尿 抗腫瘍$\cdot$ 消炎 및 抗菌에 미치는 影響 梁商殷
  11. 大韓韓醫學會誌 v.7 no.1 징가의 東西醫學的 考察 梁秀烈(외)
  12. 慶熙大學校大學院 碩士學位論文 靈芝, 山慈고, 仙鶴草, 卷柏, 瓦松이 癌細胞感受性에 미치는 影響 吳千植
  13. 大韓韓醫學會誌 v.13 no.1 蔘茸湯이 S-180에 對한 抗癌效果와 Cyclophosphamide에 依한 副作用 減少에 미치는 影響 張中植(외)
  14. 慶熙大學校大學院 碩士學位論文 仙防活命飮의 抗癌 및 免疫反應에 관한 實驗的 硏究 崔仁和
  15. 慶熙韓醫大論文集 v.18 no.1 補中益氣湯, 手拈散 및 補中益氣湯合手拈散의 抗癌과 免疫調節作用에 關한 實驗的 硏究 韓晟圭;崔昇勳(외)
  16. 大韓韓方腫瘍學會誌 v.1 no.1 열隔$\cdot$反胃와 胃癌과의 相關性에 대한 文獻的 考察 黃奎東(외)
  17. 萬病回春(上冊) v.上冊 공廷賢
  18. 癌瘤防治硏究 賈곤(著)
  19. 醫林改錯 王淸任
  20. 東垣十種醫書 李고
  21. 醫學入門 李천
  22. 類證治裁 林패琴
  23. 金궤要略釋義 湖北中醫學院(主編)
  24. 東洋醫學 v.18 no.1 癌의 中醫治療 려暢
  25. 한글판 中醫 益氣消癥方으로 治療한 末基腫瘍 臨床硏究 李萍萍(외)
  26. 中西醫結合雜誌 v.14 no.2 TRH與補中益氣湯合對應激小鼠NK活性及內分泌的傾向 湯斌
  27. 日藥理誌(Folia pharmacol. japan.) v.89 ロ-ヤルゼリ-(Royal Jelly)の抗腫瘍效果に關すゐ硏究 田村 豊行;藤井 彰(외)
  28. 濟衆新編 康命吉(편)
  29. 最新臨床檢査診斷學 김순호;손한철(외)
  30. 腫瘍學 서울대학교 의과대학(편)
  31. 韓方內科學 孫淑英(編譯)
  32. 癌瘤防治硏究 申天浩(編譯)
  33. 內科學 이문호
  34. 本草學 李尙仁
  35. 漢藥臨床應用 李尙仁;安德均(외)
  36. 醫門寶鑑 周命新
  37. 臟腑內科學 崔鍾百(編著)
  38. 암환자 한윤복;노유자(외)
  39. 새로운 統針學 韓漢洙;曺秉燁
  40. 中國醫學史 洪元植(編著)
  41. 東醫寶鑑 許凌
  42. 慶熙大學校大學院 博士學位論文 數種의 漢藥物이 白鼠의 自然殺害細胞(Natural Killer Cell)活性에 미치는 影響 姜允皓
  43. 慶熙大學校大學院 博士學位論文 鹿茸, 熱地黃, 人蔘, 五加皮가 免疫反應 및 NK細胞活性度에 미치는 影響 고병희
  44. 大韓韓方腫瘍學會誌 v.1 no.1 韓國韓醫學의 腫瘍硏究에 對한 現況 공현식(외)
  45. 慶山大學校大學院 博士學位論文 四物鱉甲靑皮湯과 四物鱉甲靑皮湯 加味方의 抗癌效果와 免疫反應에 미치는 影響 金東烈
  46. 東醫病理學會誌 v.9 抗癌制 및 放射線 副作用에 대한 韓方療法 金東熙(외)
  47. 大韓韓醫學會誌 v.16 no.2 蒲公英 分劃의 肝癌細胞에 對한 抗癌活性과 抗癌劑와의 倂用投與效果 김동희(외)
  48. 最近 癌의 豫防과 治療傾向 김삼용
  49. 東醫病理學會誌 v.8 補中益氣湯 및 少陰人補中益氣湯이 S-180에 대한 抗腫瘍效果와 Cyclophosphamide에 의한 副作用에 미치는 影響 金秀鎭;林樂哲(외)
  50. 大韓韓方腫瘍學會誌 v.1 no.1 腫瘍의 豫防과 治療를 위한 食餌療法 김진성(외)
  51. 慶熙大學校大學院 博士學位論文 四妙湯, 大柴胡湯 및 構成藥材들의 抗癌作用과 免疫反應에 관한 實驗的 硏究 金漢燮
  52. 圓光大學校大學院 博士學位論文 補中益氣湯의 投與가 紫外線照射로 低下된 마우스의 免疫機能의 恢復에 미치는 影響 閔勇泰
  53. 大韓韓醫學會誌 v.16 no.2 活血化瘀法의 癌治療 活用에 關한 考察 朴鐘鶴(외)
  54. 大韓韓方腫瘍學會誌 v.1 no.1 半夏白朮天麻湯과 半夏白朮天麻湯加味方의 抗癌效果와 免疫反應에 關한 實驗的 硏究 白泰鉉(외)
  55. 大韓韓醫會誌 v.15 no.1 積聚의 病理에 관한 文獻的 考察 徐政周(외)
  56. 大韓韓醫學會誌 v.16 no.2 紫胡, 茵蔯의 抗癌細胞에 對한 抗癌活性 및 抗癌劑와의 柏乘作用 손갑호(외)
  57. 東醫病理學會誌 v.9 韓醫學的 診斷類型에 따른 韓藥方劑의 抗癌 및 免疫調節作用에 미치는 影響 安圭錫(외)
  58. 大韓醫學協會誌 v.36 no.3 암등록 사업과 암으로 인한 사망연도별 추이 安敦姬
  59. 생약학회지 v.23 no.3 抗癌劑 Mitomycin C와 數種 複合生藥의 倂用投與 效果(I) 安文生(외)
  60. 慶熙大學校大學院 博士學位論文 六君子湯, 小紫胡湯, 魚經草 및 加味方의 抗癌作用과 免疫反應에 關한 實驗的 硏究 尹相協
  61. 癌學術誌 v.5 no.1 腫瘍과 Natural Killer (NK)細胞에 대하여 윤정구
  62. 大韓韓醫學會誌 v.10 no.2 四君子湯이 생쥐의 免疫反應 및 NK細胞의 細胞毒性에 미치는 影響 李南九;李昌鉉(외)
  63. 大韓韓醫學會誌 v.16 no.2 抗癌作用이 있는 動物類에 대한 考察 林樂哲(외)
  64. 大韓韓方腫瘍學會誌 v.1 no.1 癌腫의 病因病理에 對한 文獻的 考察 田炳旭(외)
  65. 大韓韓方腫瘍學會誌 v.1 no.1 癌에 對한 韓醫學的 認識 및 實驗的 硏究에 관한 考察 田炳旭;柳逢夏(외)
  66. 第18回全國韓醫學學術大會發表論文集 少陰人補中益氣湯과 瓦松이 抗癌 및 免疫反應에 미치는 影響 田炳旭;柳逢夏(외)
  67. 大韓韓方腫瘍學會誌 v.1 no.1 修治巴豆 및 巴豆加黃連의 細胞毒性과 抗腫瘍效果에 關한 實驗的 硏究 趙誠珏(외)
  68. 大韓韓醫學會誌 v.14 no.2 消積白朮散의 抗癌, 免疫 增强效果 및 Cisplatin의 賢臟毒性抑制에 미치는 影響에 관한 硏究 趙成基;趙鐘寬
  69. 惠和醫學 v.4 no.1 癌患者 77例에 對한 消積白朮散의 抗癌劑 副作用 減少에 미치는 效果에 關한 臨床的 考察 조진호(외)
  70. 大韓韓方腫瘍學會誌 v.1 no.1 韓醫學의 腫瘍에 대한 認識과 病理論 최승훈
  71. 大韓醫學協會誌 v.24 no.6 韓國正常人 末梢血液淋巴球의 Natural Killer(N.K) 活性置에 關한 硏究 하윤문(외)
  72. 大韓韓方腫瘍學會誌 v.1 no.1 胃癌에 對한 考察 黃奎東(외)
  73. 大韓韓醫學會誌 v.16 no.2 肺癌의 東西醫結合治療에 關한 文獻的 考察 黃忠淵
  74. 中國醫學大系 v.9 衛生寶書 東軒居士
  75. 溫病條辨 孟澍江;沈風閣(主編)
  76. 實用中醫內科學 方藥中(외)
  77. 中醫內科學 上海中醫學院(編)
  78. 中醫外科學 上海中醫學院(編)
  79. 中醫外科學 上海中醫學院(編)
  80. 老入保健中成藥 沈連生(외)
  81. 癌症的中藥治療 楊寶仁
  82. 中國醫學大系 v.12 仁齋直指方 楊士瀛
  83. 醫宗金鑑(上冊) v.上冊 吳謙(외)
  84. 難經本義 吳塤村(編著)
  85. 外臺秘要(上冊) v.上冊 王燾
  86. 靈樞經 王氷(撰)
  87. 醫學正傳 虞搏(編)
  88. 腫瘤臨證備要 李岩(編)
  89. 醫宗必讀 李中梓 著
  90. 景岳全書 張介賓
  91. 中西醫結合治療癌症 張代釗(編著)
  92. 醫學衷中參西錄(上冊) v.上冊 張錫純(著)
  93. 醫部全錄 v.12 活法機要 張元素
  94. 太平惠民和劑局方 v.三 陳師文
  95. 諸病源候論 陳杉源(編著)
  96. 婦人良方大全 v.24 陳自明(著);薛立齋(註)
  97. 中醫雜誌 六味地黃湯防法腫瘤的實驗硏究 姜延良(외)
  98. 中醫雜誌 한글판 원발성 비소세포성 肺癌 末期에 대한 中醫藥治療의 臨床觀察 唐文秀(외)
  99. 한글판 中醫雜誌 胃癌에 대한 中西醫結合治療規則硏究 潘明繼(외)
  100. 한글판中醫 健婢理氣, 化瘀軟堅, 淸熱解毒法으로 원발성肝癌을 治療 潘敏求(외)
  101. 한글판 中醫 惡性腫瘍의 治療經驗案 2例 葉景華
  102. 한글판 中西醫 結合 中晩期肺癌 211例의 臨床治療에 대한 效果分析 辛育齡
  103. 한글판 中醫 中藥 및 中藥$\cdot$放射線$\cdot$化學結合療法으로 원발성 肝癌 手術後 殘留와 再發을 治療함 林鈞華(외)
  104. 한글판 中醫雜誌 抗癌中藥의 生物治療 效用性 硏究 近況 邢雪梅(외)
  105. Medical physiology Guyton, C.
  106. Antibody formation at the cellular level in immunology Avrames, S.(et al.)
  107. Cell Imm. v.3 Antigen recognition by T-Iymphocytes I, thymus and marrow dependence of spontaneous rossete forming cells in mouse Bach, J. F.;Dardenne, M.
  108. Brit. J. Exp. path. v.34 Quantative study of the gramulopetic activity of the reticuloendomenthelial system. II, A study of Kinetics of the gramulopetic activity of the R.E.S. in the relation to the dose of carbon injected. Relationship between the weight of the organ and there activity Biozzi, G.;Benacercaf, B.;Halpren, B.N.
  109. Soc. Exp. BioI. Med. Proc. v.59;122 Thymus marrow cell combination, synergismin antibody production Clamen, H.N.(et al.)
  110. Transplantation v.5 The failure of thymus derived cells to produce antibody Davis, A.J.S.(et al.)
  111. J, Immunol. v.120 T cell growth factor : Parameters of production and a Quantitative microassay for activity Gillis, S.;Ferm, M.M.;Ou, W.;Smith, K.A.
  112. J. Immunol. v.128 Studies on induction and effector functions of concanavalin A -induced suppresor cells that limit TCGF production Gullberg, M.;Larson, E.L.
  113. J. Nat. Cancer Inst. v.51 Immunopotentiation wlth BCGII, Modulation of referance to the sheep red blood cells Miller, T.E.;Mockanes, G.B.;Lagrange, P.H.
  114. Immunology v.13 Delayed hypersensitivity in mice induced by intravenous sensitization with sheep erythrolytes, evidence for tuberculin type delayed hypersensitivity of the reaction Mitsuoka, A.;Teramatsu, M.(et al.)
  115. Cell-mediated immunity in vitro In immunology, immnophathology and immunity Sell, S.
  116. Nature v.202 A simple method for detecting single antibody forming cell Zaalberg, O.B.
  117. Nature v.202 A simple method for detecting single antibody forming cell Zaalberg, O.B.