Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Pharmaceutical Substances of Platycodon grandiflorus (jacquin) A. De Candolle

도라지의 약리성분

  • Shin, Pyung-Gyun (National Alpine Agricultural Experiment Station, RDA) ;
  • Ryu, Jin-Chang (National Agricultural Science and Technology, RDA) ;
  • Jang, Dae-Sik (Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Cho, Sung-Hwan (Department of Food Science and Technology, Gyeongsang National University) ;
  • Chung, Jin-Hwan (Department of Food Science and Technology, Gyeongsang National University)
  • 신평균 (농촌진흥청 고령지농업시험장) ;
  • 류진창 (농촌진흥청 농업과학기술원 분자유전과) ;
  • 장대식 (경상대학교 농화학과) ;
  • 조성환 (경상대학교 식품공학과) ;
  • 정진환 (경상대학교 식품공학과)
  • Published : 1997.04.28
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Abstract

Platycodon root contains abundant pharmaceutical substances and is widely used as a food and a medicinal herb. The three-year-old and the 24-year-old Platycodon roots cultivated in a local farm were analysed and compared with their pharmaceutical substances to identify the major components. Reverse column HPLC analysis of ethanol extracts from the 24-year-old roots showed some distintive peaks after the retention time of 50 min which were absent in the extracts from the three-year-old roots. This indicates that several pharmaceutical substances are present in the older roots. There were no differences in sterol composition and saponin content between the 24-year and three-year-old roots. The 15-year-old and the 23-year-old Platycodon roots, the 6-year-old Ginseng root, and the three-year-old Condonopsis root all did not show significant anticomplement activity.

도라지는 약리성분을 많이 함유하고 있으며 식품 및 생약재료로 널리 사용되고 있다. 재배도라지 24년근 및 3년근의 주요성분을 동정하기 위하여 약리성분을 분석하고 비교하였다. 재배도라지의 에탄올 추출물에서는 24년근에서 역상column을 사용한 HPLC분석에서 retention time이 약 50분 이후부터 3년근에는 보이지 않았던 peak가 나타나고 있어 연수에 따라 다수의 약리성 물질이 생성되거나 미량물질이 생성되었다. 재배도라지의 sterol 조성비 및 saponin 함량에서는 24년근과 3년근간에는 별다른 차이가 없었다. 재배도라지 15년근및23년근, 인삼6년근, 더덕3년근 모두 유의성있는 항보체 활성효과는 없었다.

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