Screening of the Angiotensin II Antagonists from Medicinal Plants

생약의 안지오텐신 II 수용체 결합저해활성 검색

  • Oh, Won-Keun (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kang, Dae-Ook (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Park, Chan-Sun (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Ahn, Soon-Cheol (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Ko, Hack-Ryong (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kim, Bo-Yeon (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Mheen, Tae-Ik (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Ahn, Jong-Seog (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Lee, Hyun-Sun (Korea Research Institute of Bioscience and Biotechnology, KIST)
  • 오원근 (생명공학연구소 바이오신소재연구부) ;
  • 강대욱 (생명공학연구소 바이오신소재연구부) ;
  • 박찬선 (생명공학연구소 바이오신소재연구부) ;
  • 안순철 (생명공학연구소 바이오신소재연구부) ;
  • 고학룡 (생명공학연구소 바이오신소재연구부) ;
  • 김보연 (생명공학연구소 바이오신소재연구부) ;
  • 민태익 (생명공학연구소 바이오신소재연구부) ;
  • 안종석 (생명공학연구소 바이오신소재연구부) ;
  • 이현선 (생명공학연구소 바이오신소재연구부)
  • Published : 1997.03.30

Abstract

The total MeOH extracts of 149 herbal medicines were screened far angiotensin ll receptor antagonistic activity using rat liver membrane fraction. Four medicinal plants- Atractylodes japonica, Evodia officinalis, Scutellaria baicalensis, Machilus thunbergii showed strong angiotensin ll antagonistic activity.

Keywords