한국균학회지 (The Korean Journal of Mycology)

한국균학회 (The Korean Society of Mycology)
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계피로부터 항진균물질 AF-001의 분리.정제 및 특성

Purification and properties of an antifungal component, AF-001, from Cinnamomi Cortex

  • 방규호 (충남대학교 미생물학과,코오롱제약 기술연구소) ;
  • 이영하 (충남대학교 미생물학과) ;
  • 민병선 (코오롱제약 기술연구소)
  • Bang, Kyu-Ho (Department of Microbiology, Chungnam National University,R & D Center, KOLON Pharmaceutical INC.) ;
  • Lee, Young-Ha (Department of Microbiology, Chungnam National University) ;
  • Min, Byung-Sun (R & D Center, KOLON Pharmaceutical INC.)
  • 발행 : 1997.12.30
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초록

계피의 항진균활성을 검색한 결과 에테르 추출물이 우수한 활성을 나타내는 것으로 평가되어 계피 에테르의 추출물로부터 항진균물질 AF-001을 분리 정제하였으며 이를 동정한 결과 trans-cinnamaldehyde로 확인되었다. AF-001은 피부진균증의 원인 균주인 Tricophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Cryptococcus neofomans, Aspergillus niger, Candida albicans와 Penicillium avellaneum에 대해 $38{\sim}79\;{\mu}g/ml$의 최소저지농도를 보였으며 imidazole계의 대표적인 항진균제인 Ketoconazole보다 광범위한 항균 스펙트럼을 보였다.

Ether extract of Cinnamomi Cortex showing antifungal activity was purified and characterized. The active component from the extract was identified to be trans-cinnamaldehyde, which was effective in inhibiting the growth of the representative fungi of dermatomycosis with minimum inhibitory concentration of $39{\sim}78\;{\mu}g/ml$. The antifungal spectrum of trans-cinnamaldehyde was broader than that of commercial antifungal agent, Ketoconazole.

키워드

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