The Korean Journal of Physiology and Pharmacology
- 제1권6호
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- Pages.797-808
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- 1997
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
기니 픽 장관 평활근에서 Sodium Nitroprusside가 장력에 미치는 영향
The Eeffect of Sodium Nitroprusside on Muscle Tension in Guinea-pig Ileum
- Kwon, Seong-Chun (Department of Physiology, Yonsei University College of Medicine) ;
- Kim, Si-Yeon (Department of Physiology, Yonsei University College of Medicine) ;
- Kim, Eun-Ju (Department of Physiology, Yonsei University College of Medicine) ;
- Kang, Bok-Soon (Department of Physiology, Yonsei University College of Medicine)
- 발행 : 1997.12.21
초록
Nitric oxide (NO) has been 3mown as a mediator of nonadrenergic, noncholinergic inhibitory neurotransmitter in intestinal smooth muscles. It has been suggested that NO donor such as sodium nitroprusside (SNP) produces relaxation of smooth muscle via activation of guanylate cyclase and elevation of cGMP levels. We have therefore investigated the effects of NO, using SNP, on muscle tension in the longitudinal smooth muscle of guinea-pig ileum. The possible role of cGMP was also investigated as well as the involvement of