YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Ginkgolides Attenuate Glutamate-Induced Neurotoxicity in Primary Cultures of Rat Cortical Cells

글루타메이트에 의한 신경독성에 미치는 징코라이드의 영향

  • Kim, So-Ra (College of Pharmacy, Seoul National University) ;
  • Jeon, Mee-Hee (The Central Pharmaceutical Affairs Council, Government Complex II) ;
  • Kim, Young-Choong (College of Pharmacy, Seoul National University)
  • 김소라 (서울대학교 약학대학) ;
  • 전미희 (보건복지부 중양약사심의위원회) ;
  • 김영중 (서울대학교 약학대학)
  • Published : 1996.12.01
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Abstract

The neurotoxicity induced by L-glutamate in primary cultures of rat cortical cells could be attenuated by diterpene constituents of Ginkgo biloba leaves, ginkgolides A, B and C. At the concentration of 100 nM, ginkgolides up-regulated the activity of glutathione reductase in primary cultures of rat cortical cells exposed to 100 ${\mu}$M glutamate. Furthermore, ginkgolides increased the content of reduced glutathione in glutamate-treated cortical cells. However, ginkgolides showed little effect in reducing superoxide dismutase activity. Ginkgolides did, however, markedly block the production of malondialdehyde, a byproduct of lipid peroxidation in glutamate-treated rat cortical cells.

Keywords

References

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