Synthesis and Biological Activity of C-3 Pyridinylethene-substituted Cephalosporins

  • Sung, Bo-Ko (Division of Applied Science Korea Institute of Science and Technology) ;
  • Lee, Yong-Sup (Division of Applied Science, Korea Institute of Science and Technology) ;
  • Lee, Jae-Yeol (Division of Applied Science, Korea Institute of Science and Technology) ;
  • Ham, Won-Hoon (College of Pharmacy, Sungkyunkwan University) ;
  • Park, Hokoon (Division of Applied Science, Korea Institute of Science and Technology)
  • Published : 1996.10.01

Abstract

A series of aminothiazolylcephalosporin derivatives (1a-1c) having pyridinylethenyl group at C-3 position was prepared starting from phosphonium salt 3 and 2-, 3- or 4-pyridinecarboxal-dehyde and the antibacterial activity of these compounds was investigated. Among them, 4-pyridinylethenyl derivative was more active than 2- and 3-pyridinylethenyl derivativees against Staphylococcus aureus and Escherichia coli.

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