Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Isolation of Handelin from Chrysanthemum boreale

  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University) ;
  • Kim, Ju-Sun (Natural Products Research Institute, Seoul National University) ;
  • Son, Kun-Ho (Department of Food and Nutrition, Andong National University) ;
  • Lee, Chong-Ock (Pharmaceutical Screening Lab., Korea Research Institute of Chemicla Technology) ;
  • Kim, Young-Hee (College of Natural Sciences, Sangji University)
  • Published : 1996.10.01
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Abstract

The flowers of Chrysanthemum boreale afforded handelin, a unique guaianolide dimer and a mixture of n-hydrocarbons and n-hydrocarbon alcohols in addition to b-sitosterol and b-sitosterol glucoside. Detailed analysis of the $^{1}H$- and $^{13}C$-NMR spectra of handelin was carried out by the application of two-dimensional $^{1}H-^{1}H$-COSY and $^{1}H$- $^{13}C$ multiple-bond, multiple-quantum spectroscopic correlation techniques. Handelin was inactive in the in vitro anti-tumor activity.

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